Contribution of central adiposity to left ventricular diastolic function (from the Baltimore Longitudinal Study of Aging)

Marco Canepa, James B. Strait, Dmitry Abramov, Yuri Milaneschi, Majd Alghatrif, Monika Moni, Ramona Ramachandran, Samer S. Najjar, Claudio Brunelli, Theodore P. Abraham, Edward G. Lakatta, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

We examined the relations of central adiposity with left ventricular (LV) diastolic dysfunction in men and women who participated in the Baltimore Longitudinal Study of Aging, a prospective community-based study of older persons. The sample for this cross-sectional analysis included 399 women and 370 men. Central adiposity was estimated using the waist circumference (WC) and global adiposity using the body mass index (BMI). Using data from a comprehensive echocardiographic study that included tissue Doppler imaging, diastolic function was graded according to 3 parameters (E/A ratio, E/Em ratio, and left atrial volume index). In the logistic regression models adjusted for age, gender, cardiovascular risk factors, and hemodynamic parameters, WC and BMI were both independently associated with LV diastolic dysfunction. However, when both WC and BMI were in the same model, only WC remained significantly associated with LV diastolic dysfunction (odds ratio 1.04, 95% confidence interval 1.01 to 1.08, p = 0.02). In the gender-stratified analyses, WC was significantly associated with LV diastolic dysfunctionindependently of BMIin women (odds ratio 1.08, 95% confidence interval 1.04 to 1.14, p <0.001) but not in men (odds ratio 1.00, 95% confidence interval 0.95 to 1.05, p = 0.91). Additional adjustment for LV mass index failed to modify these relations. In conclusion, the adverse effect of central adiposity on LV diastolic function was independent of general adiposity and more pronounced among women. The effect of visceral adiposity on LV diastolic dysfunction would benefit from confirmation in longitudinal studies.

Original languageEnglish (US)
Pages (from-to)1171-1178
Number of pages8
JournalAmerican Journal of Cardiology
Volume109
Issue number8
DOIs
StatePublished - Apr 15 2012

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Contribution of central adiposity to left ventricular diastolic function (from the Baltimore Longitudinal Study of Aging)'. Together they form a unique fingerprint.

  • Cite this

    Canepa, M., Strait, J. B., Abramov, D., Milaneschi, Y., Alghatrif, M., Moni, M., Ramachandran, R., Najjar, S. S., Brunelli, C., Abraham, T. P., Lakatta, E. G., & Ferrucci, L. (2012). Contribution of central adiposity to left ventricular diastolic function (from the Baltimore Longitudinal Study of Aging). American Journal of Cardiology, 109(8), 1171-1178. https://doi.org/10.1016/j.amjcard.2011.11.054