Contribution of bone marrow-derived endothelial cells to human tumor vasculature

Brock A. Peters, Luis A. Diaz, Kornelia Polyak, Leslie Meszler, Kathy Romans, Eva C. Guinan, Joseph H. Antin, David Myerson, Stanley R. Hamilton, Bert Vogelstein, Kenneth W. Kinzler, Christoph Lengauer

Research output: Contribution to journalArticlepeer-review

Abstract

It has been shown that bone marrow-derived stem cells can form a major fraction of the tumor endothelium in mouse tumors. To determine the role of such cells in human tumor angiogenesis, we studied six individuals who developed cancers after bone marrow transplantation with donor cells derived from individuals of the opposite sex. By performing fluorescence in situ hybridization (FISH) with sex chromosome-specific probes in conjunction with fluorescent antibody staining, we found that such stem cells indeed contributed to tumor endothelium, but at low levels, averaging only 4.9% of the total. These results illustrate substantial differences between human tumors and many mouse models with respect to angiogenesis and have important implications for the translation of experimental antiangiogenic therapies to the clinic.

Original languageEnglish (US)
Pages (from-to)261-262
Number of pages2
JournalNature medicine
Volume11
Issue number3
DOIs
StatePublished - Mar 2005

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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