Contrasting immunohistochemical localizations in rat brain of two novel K+ channels of the Shab subfamily

P. M. Hwang, M. Fotuhi, D. S. Bredt, A. M. Cunningham, S. H. Snyder

Research output: Contribution to journalArticle

Abstract

We have localized CDRK and DRK1, two novel K+ channels of the Shab subfamily by immunohistochemistry. The two channels are closely related in structure with about 90% amino acid identity in the N-terminal and middle portions and 60% identity in the C-terminal region. We observe striking differences in cellular localizations of the two channels. DRK1 tends to localize to cell bodies and proximal dendrites discretely, while CDRK is diffusely present in cell bodies and is also found on fibers in specific brain areas. In the cerebral cortex DRK1 is localized to pyramidal cells, whereas CDRK occurs in small cells, presumably interneurons. These localizations may reflect specialized delayed rectifier functions and targeting properties manifested differentially by K+ channel subfamily members.

Original languageEnglish (US)
Pages (from-to)1569-1576
Number of pages8
JournalJournal of Neuroscience
Volume13
Issue number4
StatePublished - Apr 13 1993

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Keywords

  • Purkinje cells
  • Shaker
  • granule cells
  • hippocampus
  • pyramidal neurons
  • subcellular distribution
  • targeting

ASJC Scopus subject areas

  • Neuroscience(all)

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