Contrast-enhanced ultrasound and shear wave elastography evaluation of Crohn's disease activity in three adolescent patients

Matthew A. Thimm, Carmen Cuffari, Alejandro Garcia, Sarah Sidhu, Misun Hwang

Research output: Contribution to journalArticle


Characterizing inflammation and fibrosis in Crohn's disease (CD) is necessary to guide clinical management, but distinguishing the two remains challenging. Novel ultrasound (US) techniques: contrast-enhanced US (CEUS) and shear wave elastography (SWE) offer great potential in evaluating disease activity in pediatric patients. Three patients ages 16 to 20 with known CD underwent CEUS and SWE to characterize bowel wall inflammation and fibrosis. Magnetic resonance enterography, endoscopy, or surgical pathology findings are also described when available. The patients' disease activity included acute inflammation, chronic inflammation with stricture formation, and a fibrotic surgical anastomosis without inflammation. CEUS was useful in determining the degree of inflammation, and SWE identified bowel wall fibrosis. Used together these techniques allow for better characterization of the degree of fibrosis and inflammation in bowel strictures. With further validation CEUS and SWE may allow for improved characterization of bowel strictures and disease flares in pediatric patients suffering from CD.

Original languageEnglish (US)
Pages (from-to)282-290
Number of pages9
JournalPediatric Gastroenterology, Hepatology and Nutrition
Issue number3
StatePublished - May 1 2019



  • Contrast agents
  • Crohn's disease
  • Elastography
  • Inflammatory bowel disease
  • Pediatrics
  • Ultrasound

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hepatology
  • Gastroenterology

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