Contrast-enhanced MRI lesions during treatment with interferonβ-1b predict increase in T1 black hole volume in patients with relapsing-remitting multiple sclerosis

Katrin Morgen; A. L T Crawford; R. D. Stone; R. Martin; N. D. Richert; J. A. Frank; H. F. McFarland

doi:10.1191/1352458505ms1147oa

Contrast-enhanced MRI lesions during treatment with interferonβ-1b predict increase in T1 black hole volume in patients with relapsing-remitting multiple sclerosis

Katrin Morgen, A. L T Crawford, R. D. Stone, R. Martin, N. D. Richert, J. A. Frank, H. F. McFarland

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

T1 black holes (BH) have been found to represent focal areas of substantial central nervous system tissue damage in multiple sclerosis (MS) patients. We examined the development of T1 BH over a three-year period of treatment with interferon (IFN)β-1b in a group of 20 patients with relapsing-remitting MS. The number of contrast-enhancing lesions (CEL) after one year of treatment predicted a change in the T1 BH volume in the following two years. In patients without CEL, the T1 BH volume remained stable, whereas it increased in patients with CEL. The occurrence of CEL in patients treated with IFNβ may indicate a heightened risk of accumulating T1 BH.

Original language	English (US)
Pages (from-to)	146-148
Number of pages	3
Journal	Multiple Sclerosis
Volume	11
Issue number	2
DOIs	https://doi.org/10.1191/1352458505ms1147oa
State	Published - Apr 2005
Externally published	Yes

Keywords

Black holes
Contrast-enhancing lesions
IFNβ-1b
Relapsing-remitting MS

ASJC Scopus subject areas

Clinical Neurology

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10.1191/1352458505ms1147oa

Cite this

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title = "Contrast-enhanced MRI lesions during treatment with interferonβ-1b predict increase in T1 black hole volume in patients with relapsing-remitting multiple sclerosis",

abstract = "T1 black holes (BH) have been found to represent focal areas of substantial central nervous system tissue damage in multiple sclerosis (MS) patients. We examined the development of T1 BH over a three-year period of treatment with interferon (IFN)β-1b in a group of 20 patients with relapsing-remitting MS. The number of contrast-enhancing lesions (CEL) after one year of treatment predicted a change in the T1 BH volume in the following two years. In patients without CEL, the T1 BH volume remained stable, whereas it increased in patients with CEL. The occurrence of CEL in patients treated with IFNβ may indicate a heightened risk of accumulating T1 BH.",

keywords = "Black holes, Contrast-enhancing lesions, IFNβ-1b, Relapsing-remitting MS",

author = "Katrin Morgen and Crawford, {A. L T} and Stone, {R. D.} and R. Martin and Richert, {N. D.} and Frank, {J. A.} and McFarland, {H. F.}",

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T1 - Contrast-enhanced MRI lesions during treatment with interferonβ-1b predict increase in T1 black hole volume in patients with relapsing-remitting multiple sclerosis

AU - Morgen, Katrin

AU - Crawford, A. L T

AU - Stone, R. D.

AU - Martin, R.

AU - Richert, N. D.

AU - Frank, J. A.

AU - McFarland, H. F.

PY - 2005/4

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N2 - T1 black holes (BH) have been found to represent focal areas of substantial central nervous system tissue damage in multiple sclerosis (MS) patients. We examined the development of T1 BH over a three-year period of treatment with interferon (IFN)β-1b in a group of 20 patients with relapsing-remitting MS. The number of contrast-enhancing lesions (CEL) after one year of treatment predicted a change in the T1 BH volume in the following two years. In patients without CEL, the T1 BH volume remained stable, whereas it increased in patients with CEL. The occurrence of CEL in patients treated with IFNβ may indicate a heightened risk of accumulating T1 BH.

AB - T1 black holes (BH) have been found to represent focal areas of substantial central nervous system tissue damage in multiple sclerosis (MS) patients. We examined the development of T1 BH over a three-year period of treatment with interferon (IFN)β-1b in a group of 20 patients with relapsing-remitting MS. The number of contrast-enhancing lesions (CEL) after one year of treatment predicted a change in the T1 BH volume in the following two years. In patients without CEL, the T1 BH volume remained stable, whereas it increased in patients with CEL. The occurrence of CEL in patients treated with IFNβ may indicate a heightened risk of accumulating T1 BH.

KW - Black holes

KW - Contrast-enhancing lesions

KW - IFNβ-1b

KW - Relapsing-remitting MS

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Contrast-enhanced MRI lesions during treatment with interferonβ-1b predict increase in T1 black hole volume in patients with relapsing-remitting multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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