TY - JOUR
T1 - Contractile, metabolic and arrhythmogenic effects of ionic and nonionic contrast agents in the isolated rat heart
AU - Gloth, Sean T.
AU - Gerstenblith, Gary
AU - Brinker, Jeffrey A.
N1 - Funding Information:
From the Peter Belfer Laboratory of the Cardiology Division, Department of Medicine, The Johns Hopkins Hospital. Supported by the National Heart, Lung, and Blood Institute Specialized Center of Research (SCOR) Grant No. HL 17655-E Dr. Gloth was supported by a fellowship grant from the American Heart Association, Maryland Affiliate Inc. Received for publication Oct. 31, 1991; accepted March 6, 1992. Reprint requests: Sean T. Gloth, MD, Carnegie 591, Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21205. 4/l/38903
PY - 1992/9
Y1 - 1992/9
N2 - Intracoronary administration of contrast agents may be associated with contractile dysfunction and arrhythmias. To further establish the mechanisms of these alterations, we studied high-energy phosphate metabolism, developed pressure, the occurrence of arrhythmias, and the effects of verapamil during infusion of ionic and nonionic agents in isovolumic, retrogradely perfused rat hearts using 31P nuclear magnetic resonance imaging (NMR). Diatrizoate meglumine (Renografin) infusion reduced developed pressure (DP) to 17.1 ± 3.4% (p < 0.001) of the control level, and immediately following termination of the infusion, sudden ventricular tachycardia (VT) was observed in four of six hearts. In the presence of verapamil, meglumine reduced DP to 13 ± 1.9% of control values and none of these six hearts developed VT. Iopamidol infusion in the presence of verapamil (n = 6) and alone (n = 6) resulted in a decrease in DP to 87% of control value, and no arrhythmias, significant change in high-energy phosphate levels, or changes in pH were observed. These results suggest that contrast-induced contractile depression is not mediated by changes in high-energy phosphate metabolism or pH. Arrhythmias associated with meglumine administration alone and suppressed by verapamil are probably related to calcium loading.
AB - Intracoronary administration of contrast agents may be associated with contractile dysfunction and arrhythmias. To further establish the mechanisms of these alterations, we studied high-energy phosphate metabolism, developed pressure, the occurrence of arrhythmias, and the effects of verapamil during infusion of ionic and nonionic agents in isovolumic, retrogradely perfused rat hearts using 31P nuclear magnetic resonance imaging (NMR). Diatrizoate meglumine (Renografin) infusion reduced developed pressure (DP) to 17.1 ± 3.4% (p < 0.001) of the control level, and immediately following termination of the infusion, sudden ventricular tachycardia (VT) was observed in four of six hearts. In the presence of verapamil, meglumine reduced DP to 13 ± 1.9% of control values and none of these six hearts developed VT. Iopamidol infusion in the presence of verapamil (n = 6) and alone (n = 6) resulted in a decrease in DP to 87% of control value, and no arrhythmias, significant change in high-energy phosphate levels, or changes in pH were observed. These results suggest that contrast-induced contractile depression is not mediated by changes in high-energy phosphate metabolism or pH. Arrhythmias associated with meglumine administration alone and suppressed by verapamil are probably related to calcium loading.
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U2 - 10.1016/0002-8703(92)90273-X
DO - 10.1016/0002-8703(92)90273-X
M3 - Article
C2 - 1514493
AN - SCOPUS:0026757836
SN - 0002-8703
VL - 124
SP - 651
EP - 656
JO - American heart journal
JF - American heart journal
IS - 3
ER -