Continuum of the thickness of surviving myocardial wall with single myocardial infarcts

J. S. Pirolo, G. W. Moore, G. M. Hutchins

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    Abstract

    The pathologic correlate of the clinical terms subendocardial and transmural applied to myocardial infarcts is uncertain. To examine this question, we reviewed the morphology of 204 hearts with single myocardial infarcts studied at autopsy after coronary arteriography and fixation in distension. The thickness of surviving myocardium with the infarct (S) and the thickness of the adjacent noninfarcted myocardium (A) were measured microscopically and expressed as a ratio. The S:A ratios ranged from 0.00 to 0.83. Necrosis of the entire wall (S:A ratio = 0.00) was seen in 37 (18%) cases. Distribution of the remaining cases by 10% intervals of wall necrosis (i.e., from 0.00 <S:A ratio ≤ 0.10 through 0.90 <S:A ratio ≤ 1.00) were present in 27, 33, 31, 24, 25, 12, 8, 6, 1, and 0 cases, respectively. A lower S:A ratio was correlated with infarct size, infarct expansion, infarct rupture, proximal location of the coronary artery lesion causing the infarct, recency of the infarct, and degree of endocardial mural thrombus. A higher S:A ratio was correlated with the degree of left ventricular hypertrophy. No correlation was observed between S:A ratio and several measures of coronary artery disease. Multivariate regression analysis showed that infarct expansion, infarct age, and rupture were distinct predictors of infarct thickness. The study shows that thickness of myocardium surviving with an infarct forms a continuum; there is no evidence of separate populations that would correspond to infarcts of transmural or subendocardial extent.

    Original languageEnglish (US)
    Pages (from-to)382-384
    Number of pages3
    JournalArchives of Pathology and Laboratory Medicine
    Volume110
    Issue number5
    StatePublished - 1986

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine
    • Medical Laboratory Technology

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