Continuous-wave vs. pulsed infrared laser stimulation of the rat prostate cavernous nerves

Serhat Tozburun, Christopher M. Cilip, Gwen A. Lagoda, Arthur Burnett, Nathaniel M. Fried

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optical nerve stimulation has recently been developed as an alternative to electrical nerve stimulation. However, recent studies have focused primarily on pulsed delivery of the laser radiation and at relatively low pulse rates. The objective of this study is to demonstrate faster optical stimulation of the prostate cavernous nerves using continuouswave (CW) infrared laser radiation, for potential diagnostic applications. A Thulium fiber laser (λ = 1870 nm) was used for non-contact optical stimulation of the rat prostate cavernous nerves, in vivo. Optical nerve stimulation, as measured by an intracavernous pressure (ICP) response in the penis, was achieved with the laser operating in either CW mode, or with a 5-ms pulse duration at 10, 20, 30, 40, 50, and 100 Hz. Successful optical stimulation was observed to be primarily dependent on a threshold nerve temperature (42-45°C), not an incident fluence, as previously reported. CW optical nerve stimulation provides a significantly faster ICP response time using a laser with lower power output than pulsed stimulation. CW optical nerve stimulation may therefore represent an alternative mode of stimulation for intra-operative diagnostic applications where a rapid response is critical, such as identification of the cavernous nerves during prostate cancer surgery.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7883
DOIs
StatePublished - 2011
EventPhotonic Therapeutics and Diagnostics VII - San Francisco, CA, United States
Duration: Jan 22 2011Jan 24 2011

Other

OtherPhotonic Therapeutics and Diagnostics VII
CountryUnited States
CitySan Francisco, CA
Period1/22/111/24/11

Fingerprint

Infrared lasers
nerves
Laser radiation
Pulsed lasers
stimulation
infrared lasers
rats
continuous radiation
Rats
Prostate
pulsed lasers
Lasers
Thulium
Fiber lasers
Laser modes
Surgery
Laser pulses
Infrared radiation
Radiation
Pressure

Keywords

  • cavernous nerve
  • laser
  • optical stimulation
  • prostate
  • thulium

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Tozburun, S., Cilip, C. M., Lagoda, G. A., Burnett, A., & Fried, N. M. (2011). Continuous-wave vs. pulsed infrared laser stimulation of the rat prostate cavernous nerves. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7883). [78831A] https://doi.org/10.1117/12.872876

Continuous-wave vs. pulsed infrared laser stimulation of the rat prostate cavernous nerves. / Tozburun, Serhat; Cilip, Christopher M.; Lagoda, Gwen A.; Burnett, Arthur; Fried, Nathaniel M.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883 2011. 78831A.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tozburun, S, Cilip, CM, Lagoda, GA, Burnett, A & Fried, NM 2011, Continuous-wave vs. pulsed infrared laser stimulation of the rat prostate cavernous nerves. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7883, 78831A, Photonic Therapeutics and Diagnostics VII, San Francisco, CA, United States, 1/22/11. https://doi.org/10.1117/12.872876
Tozburun S, Cilip CM, Lagoda GA, Burnett A, Fried NM. Continuous-wave vs. pulsed infrared laser stimulation of the rat prostate cavernous nerves. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883. 2011. 78831A https://doi.org/10.1117/12.872876
Tozburun, Serhat ; Cilip, Christopher M. ; Lagoda, Gwen A. ; Burnett, Arthur ; Fried, Nathaniel M. / Continuous-wave vs. pulsed infrared laser stimulation of the rat prostate cavernous nerves. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883 2011.
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