Continuous versus cyclic oral contraceptives for the treatment of endometriosis: a systematic review

Konstantinos A. Zorbas, Konstantinos P. Economopoulos, Nikos F. Vlahos

Research output: Contribution to journalArticle

Abstract

Purpose: Recurrence of endometriosis after conservative surgery has been observed in 40–50 % of patients within the first 5 years. A variety of regimens such as combined oral contraceptives, GnRH agonists, danazol, and progestins have been used postoperatively to reduce recurrence rates. Oral contraceptives (oCP) have been used either in a cyclic or in a continuous (no pill-free interval) fashion. The purpose of this article was to summarize the existing evidence on the efficacy and patient compliance for the use of oCP in a continuous versus cyclic fashion following conservative surgery for endometriosis. Methods: A systematic search of Medline identified four eligible studies. Studies were considered eligible, if they have evaluated oCP therapy, either in a cyclic or continuous regimen, after conservative surgery for endometriosis. Specifically, studies (1) reporting on women with endometriosis who were treated postoperatively with both continuous oCP and cyclic oCP, (2) written in English, (3) with minimum 6 months duration of medical treatment, and (4) with minimum 12 months duration of follow-up were considered eligible for our systematic review. Outcome measures of these eligible studies were tabulated and then analyzed cumulatively. A purely descriptive approach was adopted concerning all variables. Results: Postoperative use of continuous oCP was associated with a reduction in the recurrence rate of dysmenorrhea, delay in the presentation of dysmenorrhea, reduction in nonspecific pelvic pain, and reduction in the recurrence rate for endometrioma. Conclusions: Use of oCP in a continuous fashion following conservative surgery for endometriosis is more beneficial to cyclic use.

Original languageEnglish (US)
Pages (from-to)37-43
Number of pages7
JournalArchives of Gynecology and Obstetrics
Volume292
Issue number1
DOIs
StatePublished - Jul 18 2015
Externally publishedYes

Fingerprint

Endometriosis
Oral Contraceptives
Recurrence
Dysmenorrhea
Therapeutics
Contraceptives, Oral, Combined
Danazol
Pelvic Pain
Progestins
Patient Compliance
Gonadotropin-Releasing Hormone
Outcome Assessment (Health Care)

Keywords

  • Continuous
  • Cyclic
  • Dysmenorrhea
  • Endometriosis
  • Oral contraceptives
  • Pelvic pain

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Continuous versus cyclic oral contraceptives for the treatment of endometriosis : a systematic review. / Zorbas, Konstantinos A.; Economopoulos, Konstantinos P.; Vlahos, Nikos F.

In: Archives of Gynecology and Obstetrics, Vol. 292, No. 1, 18.07.2015, p. 37-43.

Research output: Contribution to journalArticle

Zorbas, Konstantinos A. ; Economopoulos, Konstantinos P. ; Vlahos, Nikos F. / Continuous versus cyclic oral contraceptives for the treatment of endometriosis : a systematic review. In: Archives of Gynecology and Obstetrics. 2015 ; Vol. 292, No. 1. pp. 37-43.
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