Abstract
There is evidence that the right dorsolateral prefrontal cortex (DLPFC) may play a certain role in decision making related to reward value and time perception and, in particular, in the inhibitory control of impulsive decision making. Using the theta burst stimulation (TBS) and a delay discounting (DD) task, we investigated the potential role of right DLPFC in impulsive decision making defined by the rate of discounting delayed reward. Healthy right-handed volunteers underwent three stimulation sessions, intermittent TBS (iTBS), continuous TBS (cTBS), and sham. The steepness of the discount function (k-value), reaction time for choice and consistency were measured for each subjects. cTBS of the DLPFC reduced by 36.88 % the k-value of the DD task compared to sham condition. In contrast, iTBS did not affect impulsivity level. There were no changes neither in reaction time for choice nor consistency after either the iTBS or cTBS compared with the sham stimulation. These results demonstrate that cTBS-induced modulation of cortical excitability of the right DLPFC may affect and reduce impulsive decision making. These observations may provide some insights into the role of the right DLPFC in modulating impulsivity level and calculating reward value at different time scales under less ambiguous circumstances.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 170-176 |
| Number of pages | 7 |
| Journal | Brain Stimulation |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 1 2010 |
| Externally published | Yes |
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Keywords
- decision making
- delay discounting task
- dorsolateral prefrontal cortex
- impulsivity
- rTMS
- theta burst stimulation
ASJC Scopus subject areas
- Neuroscience(all)
- Biophysics
- Clinical Neurology
Cite this
Continuous theta burst stimulation of right dorsolateral prefrontal cortex induces changes in impulsivity level. / Cho, Sang Soo; Ko, Ji Hyun; Pellecchia, Giovanna; Van Eimeren, Thilo; Cilia, Roberto; Strafella, Antonio P.
In: Brain Stimulation, Vol. 3, No. 3, 01.07.2010, p. 170-176.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Continuous theta burst stimulation of right dorsolateral prefrontal cortex induces changes in impulsivity level
AU - Cho, Sang Soo
AU - Ko, Ji Hyun
AU - Pellecchia, Giovanna
AU - Van Eimeren, Thilo
AU - Cilia, Roberto
AU - Strafella, Antonio P.
PY - 2010/7/1
Y1 - 2010/7/1
N2 - There is evidence that the right dorsolateral prefrontal cortex (DLPFC) may play a certain role in decision making related to reward value and time perception and, in particular, in the inhibitory control of impulsive decision making. Using the theta burst stimulation (TBS) and a delay discounting (DD) task, we investigated the potential role of right DLPFC in impulsive decision making defined by the rate of discounting delayed reward. Healthy right-handed volunteers underwent three stimulation sessions, intermittent TBS (iTBS), continuous TBS (cTBS), and sham. The steepness of the discount function (k-value), reaction time for choice and consistency were measured for each subjects. cTBS of the DLPFC reduced by 36.88 % the k-value of the DD task compared to sham condition. In contrast, iTBS did not affect impulsivity level. There were no changes neither in reaction time for choice nor consistency after either the iTBS or cTBS compared with the sham stimulation. These results demonstrate that cTBS-induced modulation of cortical excitability of the right DLPFC may affect and reduce impulsive decision making. These observations may provide some insights into the role of the right DLPFC in modulating impulsivity level and calculating reward value at different time scales under less ambiguous circumstances.
AB - There is evidence that the right dorsolateral prefrontal cortex (DLPFC) may play a certain role in decision making related to reward value and time perception and, in particular, in the inhibitory control of impulsive decision making. Using the theta burst stimulation (TBS) and a delay discounting (DD) task, we investigated the potential role of right DLPFC in impulsive decision making defined by the rate of discounting delayed reward. Healthy right-handed volunteers underwent three stimulation sessions, intermittent TBS (iTBS), continuous TBS (cTBS), and sham. The steepness of the discount function (k-value), reaction time for choice and consistency were measured for each subjects. cTBS of the DLPFC reduced by 36.88 % the k-value of the DD task compared to sham condition. In contrast, iTBS did not affect impulsivity level. There were no changes neither in reaction time for choice nor consistency after either the iTBS or cTBS compared with the sham stimulation. These results demonstrate that cTBS-induced modulation of cortical excitability of the right DLPFC may affect and reduce impulsive decision making. These observations may provide some insights into the role of the right DLPFC in modulating impulsivity level and calculating reward value at different time scales under less ambiguous circumstances.
KW - decision making
KW - delay discounting task
KW - dorsolateral prefrontal cortex
KW - impulsivity
KW - rTMS
KW - theta burst stimulation
UR - http://www.scopus.com/inward/record.url?scp=77957019523&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957019523&partnerID=8YFLogxK
U2 - 10.1016/j.brs.2009.10.002
DO - 10.1016/j.brs.2009.10.002
M3 - Article
C2 - 20633446
AN - SCOPUS:77957019523
VL - 3
SP - 170
EP - 176
JO - Brain Stimulation
JF - Brain Stimulation
SN - 1935-861X
IS - 3
ER -