Continuous infusion of hepatic arterial irinotecan in pretreated patients with colorectal cancer metastatic to the liver

J. M G H van Riel, C. J. van Groeningen, J. de Greve, G. Gruia, H. M. Pinedo, G. Giaccone

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Irinotecan is an active drug in colorectal cancer. In patients with liver metastases, hepatic arterial infusion of irinotecan could theoretically result in higher exposure to the drug. In order to determine the efficacy of hepatic arterial irinotecan we conducted a phase II study in pretreated patients with liver metastases of colorectal cancer. Patients and methods: Patients with measurable liver metastases of colorectal cancer with World Health Organization performance status (WHO PS) 2/day. Results: Of the 25 patients included, 22 were evaluable for response. Three of 22 patients (13.6%) had a partial response, nine (40.9%) had stable disease and 10 (45.4%) had progressive disease. No complete responses were observed. Median time to progression was 2.8 (range 1.2-23.8) months. Major toxicities were vomiting and diarrhea. There was no major hematological toxicity. Conclusions: Five-day continuous hepatic arterial infusion of irinotecan 20 mg/m2 /day has low activity in patients with liver metastases of colorectal cancer previously treated by chemotherapy.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalAnnals of Oncology
Volume15
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

Keywords

  • Clinical trial
  • Colorectal cancer
  • Intra-arterial chemotherapy
  • Irinotecan
  • Liver metastases
  • Phase II study

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Continuous infusion of hepatic arterial irinotecan in pretreated patients with colorectal cancer metastatic to the liver'. Together they form a unique fingerprint.

Cite this