Continuing evaluation of an MR compatible SPECT insert for simultaneous SPECT-MR imaging of small animals

A. Rittenbach, Jingyan Xu, A. M. El-Sharkawy, W. A. Edelstein, K. Parnham, J. Hugg, Benjamin Tsui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The goal of this conference record is to present the experiments conducted to evaluate a magnetic resonance (MR) compatible, simultaneous SPECT-MR insert for small animal (SA) imaging that we have been working on for the last three years. As previously demonstrated, the insert consists of 5 rings of 19 MR compatible CZT detectors connected seamlessly. A multi-pinhole (MPH) collimator with focused pinholes was built using a plastic shell filled with high-density coated tungsten powder and fitted with solid tungsten pinhole inserts. To acquire SPECT and MR data simultaneously, a shielded transmit/receive radio frequency (RF) coil is inserted into the MPH collimator. The insert was evaluated as a standalone SA SPECT system using both a hot-rod resolution phantom (HR-RP) experiment and SA imaging studies. Furthermore, simultaneous SPECT-MR phantom and SA imaging experiments were conducted by placing the SPECT-MR insert inside a 3T clinical MRI system. From acquired experimental data, SPECT images were reconstructed using an in-house developed 3D MPH ML-EM method with pinhole collimator detector response model and compensation. As a standalone SA SPECT system, the insert provided good quality images in phantom and SA studies. The quality of the SPECT images of the HR-RP acquired during the simultaneous SPECT-MR imaging experiment was comparable to the quality of the images acquired during standalone SPECT acquisition. Despite the fact that the SPECT insert degraded the MR image signal-to-noise-ratio (SNR) and caused field distortions, MR imaging was possible within the specific field-of-view of interest. When registered and fused, the SPECT and MR HR-RP images were found to be in acceptable geometric agreement. Data acquired during the simultaneous SPECT-MR SA study was used to obtain a dynamic SPECT image and Time Activity Curve showing initial uptake and later washout of 99mTc MAG3 into and out of a mouse's kidneys. Furthermore, a SPECT kidney image was fused with the simultaneously acquired MR image and showed acceptable geometric agreement. Fast dynamic MR imaging was not possible due to severe geometric distortions present when using high speed sequences. These experimental results demonstrate the ability of the insert to obtain SA SPECT dynamic studies and the feasibility of simultaneous SA SPECT-MR imaging. Further engineering improvements remain to be explored to reduce the interaction between the SPECT and MR systems and to eventually enable simultaneous fast dynamic MR studies over the full volume of subject animals.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium Conference Record
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781479905348
DOIs
StatePublished - 2013
Externally publishedYes
Event2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013 - Seoul, Korea, Republic of
Duration: Oct 27 2013Nov 2 2013

Other

Other2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013
CountryKorea, Republic of
CitySeoul
Period10/27/1311/2/13

Fingerprint

inserts
Single-Photon Emission-Computed Tomography
magnetic resonance
animals
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
evaluation
pinholes
collimators
rods
kidneys
Tungsten
tungsten
plastic shells
Technetium Tc 99m Mertiatide
fallout
Kidney
detectors
Feasibility Studies
Signal-To-Noise Ratio

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Rittenbach, A., Xu, J., El-Sharkawy, A. M., Edelstein, W. A., Parnham, K., Hugg, J., & Tsui, B. (2013). Continuing evaluation of an MR compatible SPECT insert for simultaneous SPECT-MR imaging of small animals. In IEEE Nuclear Science Symposium Conference Record [6829143] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2013.6829143

Continuing evaluation of an MR compatible SPECT insert for simultaneous SPECT-MR imaging of small animals. / Rittenbach, A.; Xu, Jingyan; El-Sharkawy, A. M.; Edelstein, W. A.; Parnham, K.; Hugg, J.; Tsui, Benjamin.

IEEE Nuclear Science Symposium Conference Record. Institute of Electrical and Electronics Engineers Inc., 2013. 6829143.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rittenbach, A, Xu, J, El-Sharkawy, AM, Edelstein, WA, Parnham, K, Hugg, J & Tsui, B 2013, Continuing evaluation of an MR compatible SPECT insert for simultaneous SPECT-MR imaging of small animals. in IEEE Nuclear Science Symposium Conference Record., 6829143, Institute of Electrical and Electronics Engineers Inc., 2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013, Seoul, Korea, Republic of, 10/27/13. https://doi.org/10.1109/NSSMIC.2013.6829143
Rittenbach A, Xu J, El-Sharkawy AM, Edelstein WA, Parnham K, Hugg J et al. Continuing evaluation of an MR compatible SPECT insert for simultaneous SPECT-MR imaging of small animals. In IEEE Nuclear Science Symposium Conference Record. Institute of Electrical and Electronics Engineers Inc. 2013. 6829143 https://doi.org/10.1109/NSSMIC.2013.6829143
Rittenbach, A. ; Xu, Jingyan ; El-Sharkawy, A. M. ; Edelstein, W. A. ; Parnham, K. ; Hugg, J. ; Tsui, Benjamin. / Continuing evaluation of an MR compatible SPECT insert for simultaneous SPECT-MR imaging of small animals. IEEE Nuclear Science Symposium Conference Record. Institute of Electrical and Electronics Engineers Inc., 2013.
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