Continuing Education Course #1:Non-Invasive Imaging as a Problem-Solving Tool and Translational Biomarker Strategy in Toxicologic Pathology

Richard A. Peterson, Kathy L. Gabrielson, G. Allan Johnson, Martin G. Pomper, Robert W. Coatney, Christopher T. Winkelmann

Research output: Contribution to journalReview articlepeer-review

Abstract

The continuing education course “Non-Invasive Imaging as a Problem-Solving Tool and Translational Biomarker Strategy in Toxicologic Pathology” provided a thorough overview of commonly used imaging modalities and the logistics required for integration of small animal imaging into toxicologic pathology. Non-invasive imaging (NIN) is gaining acceptance as an important modality in toxicologic pathology. This technology allows nonterminal, time-course evaluation of functional and morphologic endpoints and can be used to translate biomarkers between preclinical animal models and human patients. NIN can support drug development as well as basic research in academic or industrial environments. An initial overview of theoretical principles was followed by focused presentations on magnetic resonance imaging (MRI)/magnetic resonance microscopy (MRM), positron emission tomography (PET)/single proton emission computed tomography (SPECT), ultrasonography (US, primarily focused on echocardiography), optical (bioluminescent) imaging, and computed tomography (CT). The choice of imaging modality will depend on the research question and the needed resolution.

Original languageEnglish (US)
Pages (from-to)267-272
Number of pages6
JournalToxicologic pathology
Volume39
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • computed tomography
  • magnetic resonance imaging
  • non-invasive imaging
  • optical imaging
  • positron emission tomography
  • single proton emission computed tomography
  • ultrasound

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Toxicology
  • Cell Biology

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