Continued symptom improvement in sexually active women with overactive bladder and urgency urinary incontinence treated with tolterodine ER for 6 months

Rebecca G. Rogers, Tola Omotosho, Gloria Bachmann, Franklin Sun, Jon D. Morrow

Research output: Contribution to journalArticlepeer-review

Abstract

Improvements in overactive bladder (OAB) symptoms and health-related quality of life (HRQL) were assessed during a 24-week study of tolterodine extended release (TOL ER) in sexually active women with OAB and urgency urinary incontinence (UUI). A 12-week, double-blind, randomized, placebo-controlled trial was followed by a 12-week open-label phase. Sexually active women reported symptoms for ≥3 months. Subjects completed bladder diaries and HRQL measures at baseline and weeks 12 and 24. One hundred sixty-one women received TOL ER for 24 weeks. Women reported significant improvements in all end points at week 12 that were maintained or improved at 24 weeks. At week 24, 70% of subjects reported no UUI episodes. TOL ER resulted in improvements in OAB symptoms and HRQL that were maintained or greater with 6 months of use. Long-term compliance with OAB pharmacotherapy may be important for optimal treatment outcomes.

Original languageEnglish (US)
Pages (from-to)381-385
Number of pages5
JournalInternational Urogynecology Journal
Volume20
Issue number4
DOIs
StatePublished - Jan 1 2009

Keywords

  • Overactive bladder
  • Patient-reported outcomes
  • Urgency urinary incontinence
  • Urinary incontinence
  • Women

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Urology

Fingerprint Dive into the research topics of 'Continued symptom improvement in sexually active women with overactive bladder and urgency urinary incontinence treated with tolterodine ER for 6 months'. Together they form a unique fingerprint.

Cite this