Contemporary issues in the surgical management of pancreatic neuroendocrine tumours

Jonathan G. Sham, Michele M. Gage, Jin He

Research output: Contribution to journalArticlepeer-review


Pancreatic neuroendocrine tumours (PNET) are relatively rare entities, accounting for 1–2 per cent of pancreatic neoplasms. However, rates of diagnosis have recently increased, in part due to incidental discovery on the widespread use of cross-sectional imaging. While general consensus exists regarding the treatment of large and/or functional PNET, the management of smaller (<2 cm) asymptomatic lesions is less clear. Recent updates in staging guidelines have improved classification of high- and low-risk tumours, and additional genetic analysis (e.g. Death domain-associated protein 6 Gene, Alpha Thalassemia/Mental Retardation Syndrome X-Linked Gene) offers the possibility of enhanced risk stratification to further guide surgical management. In patients who do ultimately require pancreatectomy, the role of minimally-invasive surgery (laparoscopic or robotic) continues to expand.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalSurgical Practice
Issue number2
StatePublished - May 2019


  • gene sequencing
  • minimally invasive surgery
  • neuroendocrine
  • robotic surgery

ASJC Scopus subject areas

  • Surgery


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