Consultant's forum

Assessing homeostasis through circadian patterns

Rafael A. Irizarry, Clarke Tankersley, Robert Frank, Susan Flanders

Research output: Contribution to journalArticle

Abstract

An organism is thought to be in a dynamic state of homeostasis when each physiological and behavioral system reaches a delicate balance within the framework of other regulatory processes. Many biological systems target specific set-point variables and generate circadian patterns. In this article, we focus on specific measurements representative of two systems, namely deep-body temperature and activity counts. We examine data collected every 30 minutes in mice, assume there are underlying circadian patterns, and extend the approach presented in Brumback and Rice (1998, Journal of the American Statistical Association 93, 961-976) in order to obtain estimates in the presence of correlated data. We then assess homeostasis using these estimates and their statistical properties.

Original languageEnglish (US)
Pages (from-to)1228-1237
Number of pages10
JournalBiometrics
Volume57
Issue number4
StatePublished - 2001

Fingerprint

Homeostasis
consultants
Biological systems
Consultants
homeostasis
Correlated Data
Body Temperature
Biological Systems
Point Sets
Estimate
Statistical property
body temperature
Mouse
Count
rice
Temperature
Target
organisms
mice
Framework

Keywords

  • Circadian patterns
  • Correlated errors
  • Mixed-effects models
  • Nested curves

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Public Health, Environmental and Occupational Health
  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Mathematics
  • Statistics and Probability

Cite this

Irizarry, R. A., Tankersley, C., Frank, R., & Flanders, S. (2001). Consultant's forum: Assessing homeostasis through circadian patterns. Biometrics, 57(4), 1228-1237.

Consultant's forum : Assessing homeostasis through circadian patterns. / Irizarry, Rafael A.; Tankersley, Clarke; Frank, Robert; Flanders, Susan.

In: Biometrics, Vol. 57, No. 4, 2001, p. 1228-1237.

Research output: Contribution to journalArticle

Irizarry, RA, Tankersley, C, Frank, R & Flanders, S 2001, 'Consultant's forum: Assessing homeostasis through circadian patterns', Biometrics, vol. 57, no. 4, pp. 1228-1237.
Irizarry RA, Tankersley C, Frank R, Flanders S. Consultant's forum: Assessing homeostasis through circadian patterns. Biometrics. 2001;57(4):1228-1237.
Irizarry, Rafael A. ; Tankersley, Clarke ; Frank, Robert ; Flanders, Susan. / Consultant's forum : Assessing homeostasis through circadian patterns. In: Biometrics. 2001 ; Vol. 57, No. 4. pp. 1228-1237.
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