Construction of optically pure tryptophans from serine derived aziridine-2-carboxylates

Kazuo Sato, Alan P. Kozikowski

Research output: Contribution to journalArticle

Abstract

The possibility of preparing optically pure tryptophan derivatives from various substituted indoles and (2R)- or (2S)-2-aziridinecarboxylates has been examined. Zinc triflate was found to be the only Lewis acid capable of bringing about this reaction in moderate yields.

Original languageEnglish (US)
Pages (from-to)4073-4076
Number of pages4
JournalTetrahedron Letters
Volume30
Issue number31
DOIs
StatePublished - 1989
Externally publishedYes

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Indoles
Lewis Acids
Tryptophan
Serine
Derivatives
trifluoromethanesulfonic acid
aziridine-2-carboxylic acid

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Construction of optically pure tryptophans from serine derived aziridine-2-carboxylates. / Sato, Kazuo; Kozikowski, Alan P.

In: Tetrahedron Letters, Vol. 30, No. 31, 1989, p. 4073-4076.

Research output: Contribution to journalArticle

Sato, Kazuo ; Kozikowski, Alan P. / Construction of optically pure tryptophans from serine derived aziridine-2-carboxylates. In: Tetrahedron Letters. 1989 ; Vol. 30, No. 31. pp. 4073-4076.
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