TY - JOUR
T1 - Consistent presence of isochromosome 7q in hepatosplenic t γ/δ lymphoma
T2 - A new cytogenetic‐clinicopathologic entity
AU - Wang, Chuan‐Cheng ‐C
AU - Tien, Hwei‐Fang ‐F
AU - Lin, Ming‐Tseh ‐T
AU - Su, Ih‐Jen ‐J
AU - Wang, Chiu‐Hwa ‐H
AU - Chuang, Sou‐Ming ‐M
AU - Shen, Ming‐Ching ‐C
AU - Liu, Chen‐Hui ‐H
PY - 1995/3
Y1 - 1995/3
N2 - Peripheral T‐cell lymphoma (PTL), which is characterized by hepatosplenic presentation and the γ/δ T‐cell receptor (TCR) phenotype on the malignant cells, is a rare but distinct subtype of non‐Hodgkin's lymphomas. Little is known about the chromosomal changes in these lymphomas. We report the cytogenetic analysis of three patients who had neoplastic proliferation of T γ/δ cells in the spleen, bone marrow, and liver, but not in lymph nodes or skin. Isochromosome 7q and trisomy 8 were observed in all three patients. Isochromosome 7q as the sole abnormality has been previously reported in one patient with similar clinicopathologic features. It is suggested that i(7q) is a primary, nonrandom chromosomal abnormality in hepatosplenic T γ/δ PTL.
AB - Peripheral T‐cell lymphoma (PTL), which is characterized by hepatosplenic presentation and the γ/δ T‐cell receptor (TCR) phenotype on the malignant cells, is a rare but distinct subtype of non‐Hodgkin's lymphomas. Little is known about the chromosomal changes in these lymphomas. We report the cytogenetic analysis of three patients who had neoplastic proliferation of T γ/δ cells in the spleen, bone marrow, and liver, but not in lymph nodes or skin. Isochromosome 7q and trisomy 8 were observed in all three patients. Isochromosome 7q as the sole abnormality has been previously reported in one patient with similar clinicopathologic features. It is suggested that i(7q) is a primary, nonrandom chromosomal abnormality in hepatosplenic T γ/δ PTL.
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U2 - 10.1002/gcc.2870120302
DO - 10.1002/gcc.2870120302
M3 - Article
C2 - 7536454
AN - SCOPUS:0028945858
SN - 1045-2257
VL - 12
SP - 161
EP - 164
JO - Genes, Chromosomes and Cancer
JF - Genes, Chromosomes and Cancer
IS - 3
ER -