Consistency of isochromosome 7q and trisomy 8 in hepatosplenic γδ T- cell lymphoma: Detection by fluorescence in situ hybridization of a splenic touch-preparation from a pediatric patient

Susan Coventry, Hope H. Punnett, Ewa Z. Tomczak, Danielle Casher, Maria Koehler, Michael J. Borowitz, Constance A. Griffin, Jean Pierre De Chadarévian

Research output: Contribution to journalArticle

Abstract

Hepatosplenic gamma-delta (γδ) T-cell lymphoma is a rare but increasingly recognized lymphoid malignancy predominantly affecting young adult males. It is not well appreciated in the pediatric population. We report the third case of this aggressive lymphoma in a child as well as additional support for the consistency of the recently discovered cytogenetic abnormalities, isochromosome 7q and trisomy 8, which in this case were documented using fluorescence in situ hybridization (FISH) of a touch- preparation of the spleen.

Original languageEnglish (US)
Pages (from-to)478-483
Number of pages6
JournalPediatric and Developmental Pathology
Volume2
Issue number5
DOIs
StatePublished - Sep 1 1999

Keywords

  • Fever of unknown origin
  • Hepatosplenic lymphoma
  • Isochromosome 7q
  • Trisomy 8

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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