Considerations for the assessment of suicidal ideation and behavior in older adults with cognitive decline and dementia

Larry Alphs, H. Robert Brashear, Phillip Chappell, Yeates Conwell, Sarah Dubrava, Ni A. Khin, Nicholas Kozauer, Dean M. Hartley, David S. Miller, Rachel J. Schindler, Eric R. Siemers, Michelle Stewart, Kristine Yaffe

Research output: Contribution to journalArticle

Abstract

Introduction Better understanding of suicide risk and its management in older adults with cognitive impairment and/or dementia remain significant unmet public health needs. Urgency to address them derives from concern that CNS treatments for dementia may impact suicide risk. Regulatory guidances requiring assessment of emergent suicidal ideation and behavior (SI/SB) at every clinical trial visit emphasize the need for understanding their prevalence. Methods The literature regarding SI/SB in older persons with cognitive impairment or dementia was reviewed by an Alzheimer's Association Taskforce with emphasis on epidemiology, classification, assessment, and regulatory requirements. Results Gaps in our knowledge were identified, challenges discussed and recommendations for future work provided. Discussion Currently available SI/SB data from geriatric persons with dementia do not provide adequate understanding of its epidemiology, identification, assessment, or management. The growing public health burden of this population requires greater attention from clinicians and researchers on tactics and assessment tools to meet these needs.

Original languageEnglish (US)
Pages (from-to)48-59
Number of pages12
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Volume2
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Suicidal Ideation
Dementia
Suicide
Epidemiology
Public Health
Risk Management
Geriatrics
Research Personnel
Clinical Trials
Cognitive Dysfunction
Population

Keywords

  • Cognitive impairment
  • Dementia
  • Elderly
  • Suicidal behavior
  • Suicidal ideation
  • Suicidality
  • Suicide
  • Suicide assessment
  • Suicide risk

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology

Cite this

Considerations for the assessment of suicidal ideation and behavior in older adults with cognitive decline and dementia. / Alphs, Larry; Brashear, H. Robert; Chappell, Phillip; Conwell, Yeates; Dubrava, Sarah; Khin, Ni A.; Kozauer, Nicholas; Hartley, Dean M.; Miller, David S.; Schindler, Rachel J.; Siemers, Eric R.; Stewart, Michelle; Yaffe, Kristine.

In: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Vol. 2, No. 1, 01.01.2016, p. 48-59.

Research output: Contribution to journalArticle

Alphs, L, Brashear, HR, Chappell, P, Conwell, Y, Dubrava, S, Khin, NA, Kozauer, N, Hartley, DM, Miller, DS, Schindler, RJ, Siemers, ER, Stewart, M & Yaffe, K 2016, 'Considerations for the assessment of suicidal ideation and behavior in older adults with cognitive decline and dementia', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 2, no. 1, pp. 48-59. https://doi.org/10.1016/j.trci.2016.02.001
Alphs, Larry ; Brashear, H. Robert ; Chappell, Phillip ; Conwell, Yeates ; Dubrava, Sarah ; Khin, Ni A. ; Kozauer, Nicholas ; Hartley, Dean M. ; Miller, David S. ; Schindler, Rachel J. ; Siemers, Eric R. ; Stewart, Michelle ; Yaffe, Kristine. / Considerations for the assessment of suicidal ideation and behavior in older adults with cognitive decline and dementia. In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2016 ; Vol. 2, No. 1. pp. 48-59.
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