Considerations for Implantation Site of VX2 Carcinoma into Rabbit Liver

Kwang Hun Lee, Eleni A Liapi, Manon Buijs, Josephina Vossen, Kelvin Hong, Christos S Georgiades, Jean Francois H Geschwind

Research output: Contribution to journalArticle

Abstract

Purpose: To assess whether the implantation site of VX2 carcinoma into rabbit liver affects successful vessel selection for transcatheter arterial interventions. Materials and Methods: Twenty-four New Zealand White rabbits were randomly assigned to two groups. All implantations were performed by open laparotomy with minced tumor cells inserted into a 16-gauge Angiocath needle. Group I rabbits (n = 12) had tumor implanted into the left medial lobe of the liver and group II rabbits (n = 12) had tumor implanted into the left lateral lobe. Two weeks after implantation, selective angiography was performed for subsequent chemoembolization, which was part of a different study. Tested variables included maximum tumor diameter, tumor feeding artery size, and tumor vascularity. Results: Successful tumor growth was achieved in all rabbits. Selective angiography was possible in 33.3% of rabbits in group I and 66.6% of rabbits in group II (P <.05). Tumor size and vascularity were similar between groups. Mean lengths of tumor feeder arteries from the bifurcation of the left hepatic artery were 4.1 mm ± 1.2 in group I (left medial lobe) and 10.8 mm ± 3.0 in group II (left lateral lobe; P <.05). The angulation of the left medial lobar artery (group I) off the left hepatic artery was acute in eight of 12 rabbits (66.6%), but only four of 12 rabbits in group II (33.3%) showed acute angulation of the left lateral lobar artery off the left hepatic artery (P <.05). Mean angiography time was significantly shorter in group II. Conclusions: For selective hepatic arterial interventions, the left lateral lobe of the liver may be favorable as an implantation site for VX2 tumors in rabbits.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalJournal of Vascular and Interventional Radiology
Volume20
Issue number1
DOIs
StatePublished - Jan 2009

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Rabbits
Carcinoma
Liver
Neoplasms
Hepatic Artery
Arteries
Angiography
Laparotomy
Needles
Growth

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Considerations for Implantation Site of VX2 Carcinoma into Rabbit Liver. / Lee, Kwang Hun; Liapi, Eleni A; Buijs, Manon; Vossen, Josephina; Hong, Kelvin; Georgiades, Christos S; Geschwind, Jean Francois H.

In: Journal of Vascular and Interventional Radiology, Vol. 20, No. 1, 01.2009, p. 113-117.

Research output: Contribution to journalArticle

Lee, Kwang Hun ; Liapi, Eleni A ; Buijs, Manon ; Vossen, Josephina ; Hong, Kelvin ; Georgiades, Christos S ; Geschwind, Jean Francois H. / Considerations for Implantation Site of VX2 Carcinoma into Rabbit Liver. In: Journal of Vascular and Interventional Radiology. 2009 ; Vol. 20, No. 1. pp. 113-117.
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abstract = "Purpose: To assess whether the implantation site of VX2 carcinoma into rabbit liver affects successful vessel selection for transcatheter arterial interventions. Materials and Methods: Twenty-four New Zealand White rabbits were randomly assigned to two groups. All implantations were performed by open laparotomy with minced tumor cells inserted into a 16-gauge Angiocath needle. Group I rabbits (n = 12) had tumor implanted into the left medial lobe of the liver and group II rabbits (n = 12) had tumor implanted into the left lateral lobe. Two weeks after implantation, selective angiography was performed for subsequent chemoembolization, which was part of a different study. Tested variables included maximum tumor diameter, tumor feeding artery size, and tumor vascularity. Results: Successful tumor growth was achieved in all rabbits. Selective angiography was possible in 33.3{\%} of rabbits in group I and 66.6{\%} of rabbits in group II (P <.05). Tumor size and vascularity were similar between groups. Mean lengths of tumor feeder arteries from the bifurcation of the left hepatic artery were 4.1 mm ± 1.2 in group I (left medial lobe) and 10.8 mm ± 3.0 in group II (left lateral lobe; P <.05). The angulation of the left medial lobar artery (group I) off the left hepatic artery was acute in eight of 12 rabbits (66.6{\%}), but only four of 12 rabbits in group II (33.3{\%}) showed acute angulation of the left lateral lobar artery off the left hepatic artery (P <.05). Mean angiography time was significantly shorter in group II. Conclusions: For selective hepatic arterial interventions, the left lateral lobe of the liver may be favorable as an implantation site for VX2 tumors in rabbits.",
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AU - Georgiades, Christos S

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N2 - Purpose: To assess whether the implantation site of VX2 carcinoma into rabbit liver affects successful vessel selection for transcatheter arterial interventions. Materials and Methods: Twenty-four New Zealand White rabbits were randomly assigned to two groups. All implantations were performed by open laparotomy with minced tumor cells inserted into a 16-gauge Angiocath needle. Group I rabbits (n = 12) had tumor implanted into the left medial lobe of the liver and group II rabbits (n = 12) had tumor implanted into the left lateral lobe. Two weeks after implantation, selective angiography was performed for subsequent chemoembolization, which was part of a different study. Tested variables included maximum tumor diameter, tumor feeding artery size, and tumor vascularity. Results: Successful tumor growth was achieved in all rabbits. Selective angiography was possible in 33.3% of rabbits in group I and 66.6% of rabbits in group II (P <.05). Tumor size and vascularity were similar between groups. Mean lengths of tumor feeder arteries from the bifurcation of the left hepatic artery were 4.1 mm ± 1.2 in group I (left medial lobe) and 10.8 mm ± 3.0 in group II (left lateral lobe; P <.05). The angulation of the left medial lobar artery (group I) off the left hepatic artery was acute in eight of 12 rabbits (66.6%), but only four of 12 rabbits in group II (33.3%) showed acute angulation of the left lateral lobar artery off the left hepatic artery (P <.05). Mean angiography time was significantly shorter in group II. Conclusions: For selective hepatic arterial interventions, the left lateral lobe of the liver may be favorable as an implantation site for VX2 tumors in rabbits.

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