Considerations for Implantation Site of VX2 Carcinoma into Rabbit Liver

Kwang Hun Lee, Eleni Liapi, Manon Buijs, Josephina Vossen, Kelvin Hong, Christos Georgiades, Jean Francois H. Geschwind

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To assess whether the implantation site of VX2 carcinoma into rabbit liver affects successful vessel selection for transcatheter arterial interventions. Materials and Methods: Twenty-four New Zealand White rabbits were randomly assigned to two groups. All implantations were performed by open laparotomy with minced tumor cells inserted into a 16-gauge Angiocath needle. Group I rabbits (n = 12) had tumor implanted into the left medial lobe of the liver and group II rabbits (n = 12) had tumor implanted into the left lateral lobe. Two weeks after implantation, selective angiography was performed for subsequent chemoembolization, which was part of a different study. Tested variables included maximum tumor diameter, tumor feeding artery size, and tumor vascularity. Results: Successful tumor growth was achieved in all rabbits. Selective angiography was possible in 33.3% of rabbits in group I and 66.6% of rabbits in group II (P < .05). Tumor size and vascularity were similar between groups. Mean lengths of tumor feeder arteries from the bifurcation of the left hepatic artery were 4.1 mm ± 1.2 in group I (left medial lobe) and 10.8 mm ± 3.0 in group II (left lateral lobe; P < .05). The angulation of the left medial lobar artery (group I) off the left hepatic artery was acute in eight of 12 rabbits (66.6%), but only four of 12 rabbits in group II (33.3%) showed acute angulation of the left lateral lobar artery off the left hepatic artery (P < .05). Mean angiography time was significantly shorter in group II. Conclusions: For selective hepatic arterial interventions, the left lateral lobe of the liver may be favorable as an implantation site for VX2 tumors in rabbits.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalJournal of Vascular and Interventional Radiology
Volume20
Issue number1
DOIs
StatePublished - Jan 2009

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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