Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice, and humans

D. K. Watson, M. J. McWilliams-Smith, C. Kozak, R. Reeves, J. Gearhart, M. F. Nunn, W. Nash, J. R. Fowle, P. Duesberg, T. S. Papas

Research output: Contribution to journalArticlepeer-review

Abstract

The mammalian protooncogene homologue of the avian v-ets sequence from the E26 retrovirus consists of two sequentially distinct domains located on different chromosomes. Using somatic cell hybrid panels, we have mapped the mammalian homologue of the 5' v-ets-domain to chromosome 11 (ETS1) in man, to chromosome 9 (Ets-1) in mouse, and to chromosome D1 (ETS1) in the domestic cat. The mammalian homologue of the 3' v-ets domain was similarly mapped to human chromosome 21 (ETS2), to mouse chromosome 16 (Ets-2), and to feline chromosome C2 (ETS2). Both protooncogenes fell in syntenic groups of homologous linked loci that were conserved among the three species. The occurrence of two distinct functional protooncogenes and their conservation of linkage positions in the three mammalian orders indicate that these two genes have been separate since before the evolutionary divergence of mammals.

Original languageEnglish (US)
Pages (from-to)1792-1796
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number6
DOIs
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • General

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