TY - JOUR
T1 - Consequences of reward and nonreward conditions
T2 - Runaway behavior, neurotransmitters and physiological indicators of stress
AU - Earley, C. J.
AU - Leonard, B. E.
N1 - Funding Information:
The authors wish to thank Organon International B.V., OSS, The Netherlands for financial assistance for this project.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1979/8
Y1 - 1979/8
N2 - Rats were subjected to continuous reinforcement (CR), partial reinforcement (PR) or extinction (EX) schedules following food-motivated conditioning in a straight runway. On the final day of testing, the animals were removed from the runaway after the fifth trial and were killed in order to determine the neurochemical consequences of differential reward. Corticosterone and adrenal ascorbic acid were also taken as indicators of immediate and long-term environmental stress, respectively. From the results it would appear that PR and EX caused a prolonged period of stress as indicated by the educed ascorbic acid concentrations. However, only the PR group showed elevated concentrations of corticosterone, which would suggest that the behavioral conditions were still stressful to the PR, but not to the EX group at the time killing. Changes in the septal concentrations of GABA and hippocampal 5-HT following PR and EX were attributed to the effects of nonreward conditions. Furthermore, the catecholaminergic-olfactory system may be necessary for appropriate extinction of food-motivated behavior, while the midbrain dopaminergic system may function to maintain motivation under conditions of variable reward.
AB - Rats were subjected to continuous reinforcement (CR), partial reinforcement (PR) or extinction (EX) schedules following food-motivated conditioning in a straight runway. On the final day of testing, the animals were removed from the runaway after the fifth trial and were killed in order to determine the neurochemical consequences of differential reward. Corticosterone and adrenal ascorbic acid were also taken as indicators of immediate and long-term environmental stress, respectively. From the results it would appear that PR and EX caused a prolonged period of stress as indicated by the educed ascorbic acid concentrations. However, only the PR group showed elevated concentrations of corticosterone, which would suggest that the behavioral conditions were still stressful to the PR, but not to the EX group at the time killing. Changes in the septal concentrations of GABA and hippocampal 5-HT following PR and EX were attributed to the effects of nonreward conditions. Furthermore, the catecholaminergic-olfactory system may be necessary for appropriate extinction of food-motivated behavior, while the midbrain dopaminergic system may function to maintain motivation under conditions of variable reward.
KW - Adrenal ascorbic acid
KW - Corticosterone
KW - Food-motivated behavior
KW - Neurotransmitters
KW - Nonreward
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U2 - 10.1016/0091-3057(79)90016-9
DO - 10.1016/0091-3057(79)90016-9
M3 - Article
C2 - 41263
AN - SCOPUS:0018674292
SN - 0091-3057
VL - 11
SP - 215
EP - 219
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 2
ER -