Consequences of estrogen deprivation and the rationale for hormone replacement therapy

C. B. Hammond, C. E. Rackley, J. Fiorica, A. Morrison, S. Wysocki

Research output: Contribution to journalArticle

Abstract

Menopause results in a fairly precipitous decline in estrogen levels. This estrogen deprivation is probably associated with a number of consequences, including osteoporosis, tooth loss, cardiovascular disease, stroke, age-related macular degeneration colon cancer, diabetes mellitus, Alzheimer's disease, and Parkinsons's disease. Coronary artery disease is the most frequent cause of death in women age 50 years and older, yet most women report a fear of dying from breast cancer. Current data suggest that women who take some form of hormone replacement therapy (HRT) after menopause can reduce their cardiovascular mortality approximately 50%, yet many stop taking HRT - or never start - because of this fear. Although use of estrogen replacement therapy and HRT (after a diagnosis of breast cancer) currently is contraindicated for at least 5 years by the US Food and Drug Administration, 3 studies have found that women who took hormones had no greater incidence of breast cancer recurrence than the general breast cancer population. Evidence suggest HRT has a beneficial effect on the central nervous system, including on neurotransmitter systems within the brain that are implicated in mood disorders and depression; learning, memory, and Alzheimer's disease; and movement disorders such as Parkinson's disease. When women are counseled about the benefits and risks of HRT and alternative therapies, it may help for physicians to keep in mind that women are more than a sum of their estrogen receptors: their emotions and beliefs will influence how they view menopause and their receptivity to available therapeutic options.

Original languageEnglish (US)
JournalAmerican Journal of Managed Care
Volume6
Issue number14 SUPPL.
StatePublished - 2000
Externally publishedYes

Fingerprint

Hormone Replacement Therapy
deprivation
Estrogens
cancer
menopause
Menopause
Breast Neoplasms
Disease
Fear
Parkinson Disease
dementia
Alzheimer Disease
Tooth Loss
Estrogen Replacement Therapy
anxiety
Movement Disorders
Macular Degeneration
United States Food and Drug Administration
bone disease
Complementary Therapies

ASJC Scopus subject areas

  • Medicine(all)
  • Nursing(all)
  • Health(social science)
  • Health Professions(all)

Cite this

Hammond, C. B., Rackley, C. E., Fiorica, J., Morrison, A., & Wysocki, S. (2000). Consequences of estrogen deprivation and the rationale for hormone replacement therapy. American Journal of Managed Care, 6(14 SUPPL.).

Consequences of estrogen deprivation and the rationale for hormone replacement therapy. / Hammond, C. B.; Rackley, C. E.; Fiorica, J.; Morrison, A.; Wysocki, S.

In: American Journal of Managed Care, Vol. 6, No. 14 SUPPL., 2000.

Research output: Contribution to journalArticle

Hammond, CB, Rackley, CE, Fiorica, J, Morrison, A & Wysocki, S 2000, 'Consequences of estrogen deprivation and the rationale for hormone replacement therapy', American Journal of Managed Care, vol. 6, no. 14 SUPPL..
Hammond CB, Rackley CE, Fiorica J, Morrison A, Wysocki S. Consequences of estrogen deprivation and the rationale for hormone replacement therapy. American Journal of Managed Care. 2000;6(14 SUPPL.).
Hammond, C. B. ; Rackley, C. E. ; Fiorica, J. ; Morrison, A. ; Wysocki, S. / Consequences of estrogen deprivation and the rationale for hormone replacement therapy. In: American Journal of Managed Care. 2000 ; Vol. 6, No. 14 SUPPL.
@article{fc963bc9ce1f490b93463300201b7f3f,
title = "Consequences of estrogen deprivation and the rationale for hormone replacement therapy",
abstract = "Menopause results in a fairly precipitous decline in estrogen levels. This estrogen deprivation is probably associated with a number of consequences, including osteoporosis, tooth loss, cardiovascular disease, stroke, age-related macular degeneration colon cancer, diabetes mellitus, Alzheimer's disease, and Parkinsons's disease. Coronary artery disease is the most frequent cause of death in women age 50 years and older, yet most women report a fear of dying from breast cancer. Current data suggest that women who take some form of hormone replacement therapy (HRT) after menopause can reduce their cardiovascular mortality approximately 50{\%}, yet many stop taking HRT - or never start - because of this fear. Although use of estrogen replacement therapy and HRT (after a diagnosis of breast cancer) currently is contraindicated for at least 5 years by the US Food and Drug Administration, 3 studies have found that women who took hormones had no greater incidence of breast cancer recurrence than the general breast cancer population. Evidence suggest HRT has a beneficial effect on the central nervous system, including on neurotransmitter systems within the brain that are implicated in mood disorders and depression; learning, memory, and Alzheimer's disease; and movement disorders such as Parkinson's disease. When women are counseled about the benefits and risks of HRT and alternative therapies, it may help for physicians to keep in mind that women are more than a sum of their estrogen receptors: their emotions and beliefs will influence how they view menopause and their receptivity to available therapeutic options.",
author = "Hammond, {C. B.} and Rackley, {C. E.} and J. Fiorica and A. Morrison and S. Wysocki",
year = "2000",
language = "English (US)",
volume = "6",
journal = "American Journal of Managed Care",
issn = "1088-0224",
publisher = "Ascend Media",
number = "14 SUPPL.",

}

TY - JOUR

T1 - Consequences of estrogen deprivation and the rationale for hormone replacement therapy

AU - Hammond, C. B.

AU - Rackley, C. E.

AU - Fiorica, J.

AU - Morrison, A.

AU - Wysocki, S.

PY - 2000

Y1 - 2000

N2 - Menopause results in a fairly precipitous decline in estrogen levels. This estrogen deprivation is probably associated with a number of consequences, including osteoporosis, tooth loss, cardiovascular disease, stroke, age-related macular degeneration colon cancer, diabetes mellitus, Alzheimer's disease, and Parkinsons's disease. Coronary artery disease is the most frequent cause of death in women age 50 years and older, yet most women report a fear of dying from breast cancer. Current data suggest that women who take some form of hormone replacement therapy (HRT) after menopause can reduce their cardiovascular mortality approximately 50%, yet many stop taking HRT - or never start - because of this fear. Although use of estrogen replacement therapy and HRT (after a diagnosis of breast cancer) currently is contraindicated for at least 5 years by the US Food and Drug Administration, 3 studies have found that women who took hormones had no greater incidence of breast cancer recurrence than the general breast cancer population. Evidence suggest HRT has a beneficial effect on the central nervous system, including on neurotransmitter systems within the brain that are implicated in mood disorders and depression; learning, memory, and Alzheimer's disease; and movement disorders such as Parkinson's disease. When women are counseled about the benefits and risks of HRT and alternative therapies, it may help for physicians to keep in mind that women are more than a sum of their estrogen receptors: their emotions and beliefs will influence how they view menopause and their receptivity to available therapeutic options.

AB - Menopause results in a fairly precipitous decline in estrogen levels. This estrogen deprivation is probably associated with a number of consequences, including osteoporosis, tooth loss, cardiovascular disease, stroke, age-related macular degeneration colon cancer, diabetes mellitus, Alzheimer's disease, and Parkinsons's disease. Coronary artery disease is the most frequent cause of death in women age 50 years and older, yet most women report a fear of dying from breast cancer. Current data suggest that women who take some form of hormone replacement therapy (HRT) after menopause can reduce their cardiovascular mortality approximately 50%, yet many stop taking HRT - or never start - because of this fear. Although use of estrogen replacement therapy and HRT (after a diagnosis of breast cancer) currently is contraindicated for at least 5 years by the US Food and Drug Administration, 3 studies have found that women who took hormones had no greater incidence of breast cancer recurrence than the general breast cancer population. Evidence suggest HRT has a beneficial effect on the central nervous system, including on neurotransmitter systems within the brain that are implicated in mood disorders and depression; learning, memory, and Alzheimer's disease; and movement disorders such as Parkinson's disease. When women are counseled about the benefits and risks of HRT and alternative therapies, it may help for physicians to keep in mind that women are more than a sum of their estrogen receptors: their emotions and beliefs will influence how they view menopause and their receptivity to available therapeutic options.

UR - http://www.scopus.com/inward/record.url?scp=0033813738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033813738&partnerID=8YFLogxK

M3 - Article

C2 - 11184072

AN - SCOPUS:0033813738

VL - 6

JO - American Journal of Managed Care

JF - American Journal of Managed Care

SN - 1088-0224

IS - 14 SUPPL.

ER -