TY - JOUR
T1 - Consequences of epilepsy in the developing brain
T2 - Implications for surgical management
AU - Stafstrom, Carl E.
AU - Lynch, Michael
AU - Sutula, Thomas P.
N1 - Funding Information:
From the Departments of Neurology and Pediatrics, University of Wisconsin, Madison, WI. Supported in part by NINDS 25020 (TPS) and The Charlie Foundation ( CES). Address reprint requests to Carl E. Stafstrom, MD, PhD, Department of Neurology, CSC H4-614, University of Wisconsin, 600 Highland Ave, Madison, W153792. Copyright 9 2000 by W.B. Saunders Company 1071-9091/00/0703-0002510.00/0 doi: 10.1053/spen. 2000.16651
PY - 2000
Y1 - 2000
N2 - The developing brain is highly susceptible to seizures, as demonstrated by both human and animal studies. Until recently, the brain has been considered to be relatively resistant to damage induced by seizures early in life. Accumulating evidence in animal models now suggests that early seizures can cause structural and physiologic changes in developing neural circuits that result in permanent alterations in the balance between neuronal excitation and inhibition, deficits in cognitive function, and increased susceptibility to additional seizures. The disruption of normal neuronal activity by seizures can affect multiple developmental processes, resulting in these long-lasting changes. These data should be considered in the clinical approach to children with intractable epilepsy and suggest that early intervention may avoid some of these long-term neurologic deficits. Copyright (C) 2000 by W.B. Saunders Company.
AB - The developing brain is highly susceptible to seizures, as demonstrated by both human and animal studies. Until recently, the brain has been considered to be relatively resistant to damage induced by seizures early in life. Accumulating evidence in animal models now suggests that early seizures can cause structural and physiologic changes in developing neural circuits that result in permanent alterations in the balance between neuronal excitation and inhibition, deficits in cognitive function, and increased susceptibility to additional seizures. The disruption of normal neuronal activity by seizures can affect multiple developmental processes, resulting in these long-lasting changes. These data should be considered in the clinical approach to children with intractable epilepsy and suggest that early intervention may avoid some of these long-term neurologic deficits. Copyright (C) 2000 by W.B. Saunders Company.
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U2 - 10.1053/spen.2000.16651
DO - 10.1053/spen.2000.16651
M3 - Article
C2 - 11023172
AN - SCOPUS:0033798595
SN - 1071-9091
VL - 7
SP - 147
EP - 157
JO - Seminars in Pediatric Neurology
JF - Seminars in Pediatric Neurology
IS - 3
ER -