TY - JOUR
T1 - Consensus statement understanding health and malnutrition through a systems approach
T2 - The ENOUGH program for early life
AU - Kaput, Jim
AU - Van Ommen, Ben
AU - Kremer, Bas
AU - Priami, Corrado
AU - Monteiro, Jacqueline Pontes
AU - Morine, Melissa
AU - Pepping, Fre
AU - Diaz, Zoey
AU - Fenech, Michael
AU - He, Yiwu
AU - Albers, Ruud
AU - Drevon, Christian A.
AU - Evelo, Chris T.
AU - Hancock, Robert E.W.
AU - Ijsselmuiden, Carel
AU - Lumey, L. H.
AU - Minihane, Anne Marie
AU - Muller, Michael
AU - Murgia, Chiara
AU - Radonjic, Marijana
AU - Sobral, Bruno
AU - West, Keith P.
N1 - Funding Information:
Acknowledgments This manuscript emerged from a workshop entitled A Systems Nutrition Approach to Essential Nutrients (Wa-geningen, The Netherlands. 7–9 November 2012). The aim of the meeting was to discuss whether systems biology approaches could contribute to research on essential nutrient malnutrition. Participants (author status) from the fields of systems biology, omics technologies, ethics, capacity building, immunity, and international nutrition contributed to the workshop. Discussions focused on the related topics of immune function and infectious disease susceptibility in the malnourished, metabolic health including growth and cognitive function, bioinformatics needs and computational methods for system analysis, ethics, and sustainability. The workshop was cosponsored by the Bill and Melinda Gates Foundation, the Nestle Institute of Health Sciences, DSM, The Microsoft Research-University of Trento Institute of Computational and Systems Biology (COSBI), Wageningen University, and NuGO. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. JK and BS are employed by Nestle Institute of Health Sciences, a for-profit NESTEC company. However, no specific funding was provided for this work except for the sponsorship of the workshop. RAH is the Canada Research Chair and is funded by the Canadian Institutes for Health Research. BK, MR, and BvO are employed by TNO, a not-for-profit organization regulated by public law. TNO is an independent research organization dealing with health-related research, not part of any government, university or company. The organization may benefit from its knowledge, by supporting companies in their product development by consultancy and research. In these cases, the authors will not receive additional salary, additional personal income, or any form of financial support.
PY - 2014/1
Y1 - 2014/1
N2 - Nutrition research, like most biomedical disciplines, adopted and often uses experimental approaches based on Beadle and Tatum's one gene - one polypeptide hypothesis, thereby reducing biological processes to single reactions or pathways. Systems thinking is needed to understand the complexity of health and disease processes requiring measurements of physiological processes, as well as environmental and social factors, which may alter the expression of genetic information. Analysis of physiological processes with omics technologies to assess systems' responses has only become available over the past decade and remains costly. Studies of environmental and social conditions known to alter health are often not connected to biomedical research. While these facts are widely accepted, developing and conducting comprehensive research programs for health are often beyond financial and human resources of single research groups. We propose a new research program on essential nutrients for optimal underpinning of growth and health (ENOUGH) that will use systems approaches with more comprehensive measurements and biostatistical analysis of the many biological and environmental factors that influence undernutrition. Creating a knowledge base for nutrition and health is a necessary first step toward developing solutions targeted to different populations in diverse social and physical environments for the two billion undernourished people in developed and developing economies.
AB - Nutrition research, like most biomedical disciplines, adopted and often uses experimental approaches based on Beadle and Tatum's one gene - one polypeptide hypothesis, thereby reducing biological processes to single reactions or pathways. Systems thinking is needed to understand the complexity of health and disease processes requiring measurements of physiological processes, as well as environmental and social factors, which may alter the expression of genetic information. Analysis of physiological processes with omics technologies to assess systems' responses has only become available over the past decade and remains costly. Studies of environmental and social conditions known to alter health are often not connected to biomedical research. While these facts are widely accepted, developing and conducting comprehensive research programs for health are often beyond financial and human resources of single research groups. We propose a new research program on essential nutrients for optimal underpinning of growth and health (ENOUGH) that will use systems approaches with more comprehensive measurements and biostatistical analysis of the many biological and environmental factors that influence undernutrition. Creating a knowledge base for nutrition and health is a necessary first step toward developing solutions targeted to different populations in diverse social and physical environments for the two billion undernourished people in developed and developing economies.
KW - Essential nutrients for optimal
KW - Health
KW - Malnutrition
KW - Systems nutrition research
KW - Underpinning of growth and health
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U2 - 10.1007/s12263-013-0378-y
DO - 10.1007/s12263-013-0378-y
M3 - Review article
C2 - 24363221
AN - SCOPUS:84893056912
SN - 1555-8932
VL - 9
JO - Genes and Nutrition
JF - Genes and Nutrition
IS - 1
M1 - 378
ER -