TY - JOUR
T1 - Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease
AU - Donahue, Manus J.
AU - Achten, Eric
AU - Cogswell, Petrice M.
AU - De Leeuw, Frank Erik
AU - Derdeyn, Colin P.
AU - Dijkhuizen, Rick M.
AU - Fan, Audrey P.
AU - Ghaznawi, Rashid
AU - Heit, Jeremy J.
AU - Ikram, M. Arfan
AU - Jezzard, Peter
AU - Jordan, Lori C.
AU - Jouvent, Eric
AU - Knutsson, Linda
AU - Leigh, Richard
AU - Liebeskind, David S.
AU - Lin, Weili
AU - Okell, Thomas W.
AU - Qureshi, Adnan I.
AU - Stagg, Charlotte J.
AU - van Osch, Matthias J.P.
AU - van Zijl, Peter C.M.
AU - Watchmaker, Jennifer M.
AU - Wintermark, Max
AU - Wu, Ona
AU - Zaharchuk, Greg
AU - Zhou, Jinyuan
AU - Hendrikse, Jeroen
N1 - Funding Information:
1Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA 2Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA 3Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, USA 4Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, USA 5Department of Radiology and Nuclear Medicine, Universiteit Gent, Gent, Belgium 6Radboud University, Nijmegen Medical Center, Donders Institute Brain Cognition & Behaviour, Center for Neuroscience, Department of Neurology, Nijmegen, The Netherlands 7Department of Radiology and Neurology, University of Iowa, Iowa City, IA, USA 8Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands 9Department of Radiology, Stanford University, Stanford, CA, USA 10Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands 11Department of Radiology, Neuroimaging and Neurointervention Division, Stanford University, CA, USA 12Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands 13Department of Radiology, Erasmus MC, Rotterdam, The Netherlands 14Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK 15Department of Pediatrics, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, USA 16Department of Neurology, AP-HP, Lariboisière Hospital, Paris, France 17Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA 18Department of Medical Radiation Physics, Lund University, Lund, Sweden 19National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA 20Neurovascular Imaging Research Core, UCLA, Los Angeles, CA, USA 21Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA 22Department of Neurology, Zeenat Qureshi Stroke Institute, St. Cloud, MN, USA 23Oxford Centre for Human Brain Activity, University of Oxford, Oxford, UK 24Department of Radiology, Leiden Medical Center, Leiden, The Netherlands 25F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA 26Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA 27Department of Radiology, Harvard Medical School, Boston, MA, USA
Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: MJD is supported by the American Heart Association (14CSA20380466 and 14GRNT20150004), NIH/NINDS (5R01NS078828, 1R01NS097763), and NIH/NINR (6R01NR015079). F-EdL is supported by a clinical established investigator grant of the Dutch Heart Foundation (grant number 2014 T060) and by a VIDI innovational grant from The Netherlands Organisation for Health Research and Development (ZonMw grant 016.126.351). MAI is funded through the Netherlands Heart Foundation (2012T008). TWO is supported by the Royal Academy of Engineering. JH has received funding from the European Research Council under the European Union’s Horizon 2020 Programme (H2020)/ERC grant agreement n°637024 (HEARTOFSTROKE), H2020 grant agreement No 666881, SVDs@target and receives salary support by from the Netherlands Organization for Scientific Research (NWO) under grant n°91712322.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recovery mechanisms. Underlying pathophysiology as it relates to large vessel steno-occlusive disease and the impact of this macrovascular disease on tissue-level viability, hemodynamics (cerebral blood flow, cerebral blood volume, and mean transit time), and metabolism (cerebral metabolic rate of oxygen consumption and pH) are also discussed in the context of emerging neuroimaging protocols with sensitivity to these factors. The overall purpose is to highlight advancements in stroke care and diagnostics and to provide a general overview of emerging research topics that have potential for reducing morbidity in multiple areas of CVD.
AB - Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recovery mechanisms. Underlying pathophysiology as it relates to large vessel steno-occlusive disease and the impact of this macrovascular disease on tissue-level viability, hemodynamics (cerebral blood flow, cerebral blood volume, and mean transit time), and metabolism (cerebral metabolic rate of oxygen consumption and pH) are also discussed in the context of emerging neuroimaging protocols with sensitivity to these factors. The overall purpose is to highlight advancements in stroke care and diagnostics and to provide a general overview of emerging research topics that have potential for reducing morbidity in multiple areas of CVD.
KW - Stroke
KW - cerebrovascular disease
KW - hemodynamics
KW - imaging
KW - metabolism
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U2 - 10.1177/0271678X17721830
DO - 10.1177/0271678X17721830
M3 - Review article
C2 - 28816594
AN - SCOPUS:85046007845
VL - 38
SP - 1391
EP - 1417
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 9
ER -