TY - JOUR
T1 - Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease
AU - Donahue, Manus J.
AU - Achten, Eric
AU - Cogswell, Petrice M.
AU - De Leeuw, Frank Erik
AU - Derdeyn, Colin P.
AU - Dijkhuizen, Rick M.
AU - Fan, Audrey P.
AU - Ghaznawi, Rashid
AU - Heit, Jeremy J.
AU - Ikram, M. Arfan
AU - Jezzard, Peter
AU - Jordan, Lori C.
AU - Jouvent, Eric
AU - Knutsson, Linda
AU - Leigh, Richard
AU - Liebeskind, David S.
AU - Lin, Weili
AU - Okell, Thomas W.
AU - Qureshi, Adnan I.
AU - Stagg, Charlotte J.
AU - van Osch, Matthias J.P.
AU - van Zijl, Peter C.M.
AU - Watchmaker, Jennifer M.
AU - Wintermark, Max
AU - Wu, Ona
AU - Zaharchuk, Greg
AU - Zhou, Jinyuan
AU - Hendrikse, Jeroen
N1 - Publisher Copyright:
© The Author(s) 2017.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recovery mechanisms. Underlying pathophysiology as it relates to large vessel steno-occlusive disease and the impact of this macrovascular disease on tissue-level viability, hemodynamics (cerebral blood flow, cerebral blood volume, and mean transit time), and metabolism (cerebral metabolic rate of oxygen consumption and pH) are also discussed in the context of emerging neuroimaging protocols with sensitivity to these factors. The overall purpose is to highlight advancements in stroke care and diagnostics and to provide a general overview of emerging research topics that have potential for reducing morbidity in multiple areas of CVD.
AB - Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recovery mechanisms. Underlying pathophysiology as it relates to large vessel steno-occlusive disease and the impact of this macrovascular disease on tissue-level viability, hemodynamics (cerebral blood flow, cerebral blood volume, and mean transit time), and metabolism (cerebral metabolic rate of oxygen consumption and pH) are also discussed in the context of emerging neuroimaging protocols with sensitivity to these factors. The overall purpose is to highlight advancements in stroke care and diagnostics and to provide a general overview of emerging research topics that have potential for reducing morbidity in multiple areas of CVD.
KW - Stroke
KW - cerebrovascular disease
KW - hemodynamics
KW - imaging
KW - metabolism
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U2 - 10.1177/0271678X17721830
DO - 10.1177/0271678X17721830
M3 - Review article
C2 - 28816594
AN - SCOPUS:85046007845
SN - 0271-678X
VL - 38
SP - 1391
EP - 1417
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 9
ER -