Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease

Manus J. Donahue, Eric Achten, Petrice M. Cogswell, Frank Erik De Leeuw, Colin P. Derdeyn, Rick M. Dijkhuizen, Audrey P. Fan, Rashid Ghaznawi, Jeremy J. Heit, M. Arfan Ikram, Peter Jezzard, Lori C. Jordan, Eric Jouvent, Linda Knutsson, Richard Leigh, David S. Liebeskind, Weili Lin, Thomas W. Okell, Adnan I. Qureshi, Charlotte J. StaggMatthias J.P. van Osch, Peter C.M. van Zijl, Jennifer M. Watchmaker, Max Wintermark, Ona Wu, Greg Zaharchuk, Jinyuan Zhou, Jeroen Hendrikse

Research output: Contribution to journalArticle

Abstract

Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recovery mechanisms. Underlying pathophysiology as it relates to large vessel steno-occlusive disease and the impact of this macrovascular disease on tissue-level viability, hemodynamics (cerebral blood flow, cerebral blood volume, and mean transit time), and metabolism (cerebral metabolic rate of oxygen consumption and pH) are also discussed in the context of emerging neuroimaging protocols with sensitivity to these factors. The overall purpose is to highlight advancements in stroke care and diagnostics and to provide a general overview of emerging research topics that have potential for reducing morbidity in multiple areas of CVD.

Original languageEnglish (US)
JournalJournal of Cerebral Blood Flow and Metabolism
DOIs
StateAccepted/In press - Jan 1 2017

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Cerebrovascular Disorders
Stroke
Cerebrovascular Circulation
Tissue Survival
Developed Countries
Neuroimaging
Oxygen Consumption
Cause of Death
Hemodynamics
Morbidity
Research

Keywords

  • cerebrovascular disease
  • hemodynamics
  • imaging
  • metabolism
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Donahue, M. J., Achten, E., Cogswell, P. M., De Leeuw, F. E., Derdeyn, C. P., Dijkhuizen, R. M., ... Hendrikse, J. (Accepted/In press). Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease. Journal of Cerebral Blood Flow and Metabolism. https://doi.org/10.1177/0271678X17721830

Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease. / Donahue, Manus J.; Achten, Eric; Cogswell, Petrice M.; De Leeuw, Frank Erik; Derdeyn, Colin P.; Dijkhuizen, Rick M.; Fan, Audrey P.; Ghaznawi, Rashid; Heit, Jeremy J.; Ikram, M. Arfan; Jezzard, Peter; Jordan, Lori C.; Jouvent, Eric; Knutsson, Linda; Leigh, Richard; Liebeskind, David S.; Lin, Weili; Okell, Thomas W.; Qureshi, Adnan I.; Stagg, Charlotte J.; van Osch, Matthias J.P.; van Zijl, Peter C.M.; Watchmaker, Jennifer M.; Wintermark, Max; Wu, Ona; Zaharchuk, Greg; Zhou, Jinyuan; Hendrikse, Jeroen.

In: Journal of Cerebral Blood Flow and Metabolism, 01.01.2017.

Research output: Contribution to journalArticle

Donahue, MJ, Achten, E, Cogswell, PM, De Leeuw, FE, Derdeyn, CP, Dijkhuizen, RM, Fan, AP, Ghaznawi, R, Heit, JJ, Ikram, MA, Jezzard, P, Jordan, LC, Jouvent, E, Knutsson, L, Leigh, R, Liebeskind, DS, Lin, W, Okell, TW, Qureshi, AI, Stagg, CJ, van Osch, MJP, van Zijl, PCM, Watchmaker, JM, Wintermark, M, Wu, O, Zaharchuk, G, Zhou, J & Hendrikse, J 2017, 'Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease', Journal of Cerebral Blood Flow and Metabolism. https://doi.org/10.1177/0271678X17721830
Donahue, Manus J. ; Achten, Eric ; Cogswell, Petrice M. ; De Leeuw, Frank Erik ; Derdeyn, Colin P. ; Dijkhuizen, Rick M. ; Fan, Audrey P. ; Ghaznawi, Rashid ; Heit, Jeremy J. ; Ikram, M. Arfan ; Jezzard, Peter ; Jordan, Lori C. ; Jouvent, Eric ; Knutsson, Linda ; Leigh, Richard ; Liebeskind, David S. ; Lin, Weili ; Okell, Thomas W. ; Qureshi, Adnan I. ; Stagg, Charlotte J. ; van Osch, Matthias J.P. ; van Zijl, Peter C.M. ; Watchmaker, Jennifer M. ; Wintermark, Max ; Wu, Ona ; Zaharchuk, Greg ; Zhou, Jinyuan ; Hendrikse, Jeroen. / Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease. In: Journal of Cerebral Blood Flow and Metabolism. 2017.
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