Consensus guidelines from the American Society of Peritoneal Surface Malignancies on standardizing the delivery of hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal cancer patients in the United States

K. Turaga, E. Levine, R. Barone, R. Sticca, N. Petrelli, L. Lambert, G. Nash, M. Morse, R. Adbel-Misih, H. R. Alexander, F. Attiyeh, D. Bartlett, A. Bastidas, T. Blazer, Q. Chu, K. Chung, L. Dominguez-Parra, N. J. Espat, J. Foster, K. FournierR. Garcia, M. Goodman, N. Hanna, L. Harrison, R. Hoefer, M. Holtzman, J. Kane, D. Labow, B. Li, A. Lowy, P. Mansfield, E. Ong, C. Pameijer, J. Pingpank, M. Quinones, R. Royal, G. Salti, A. Sardi, P. Shen, J. Skitzki, J. Spellman, J. Stewart, J. Esquivel

Research output: Contribution to journalArticlepeer-review

115 Scopus citations

Abstract

Background: The American Society of Peritoneal Surface Malignancies (ASPSM) is a consortium of cancer centers performing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). This is a position paper from the ASPSM on the standardization of the delivery of HIPEC. Methods: A survey was conducted of all cancer centers performing HIPEC in the United States. We attempted to obtain consensus by the modified method of Delphi on seven key HIPEC parameters: (1) method, (2) inflow temperature, (3) perfusate volume, (4) drug, (5) dosage, (6) timing of drug delivery, and (7) total perfusion time. Statistical analysis was performed using nonparametric tests. Results: Response rates for ASPSM members (n = 45) and non-ASPSM members (n = 24) were 89 and 33 %, respectively. Of the responders from ASPSM members, 95 % agreed with implementing the proposal. Majority of the surgical oncologists favored the closed method of delivery with a standardized dual dose of mitomycin for a 90-min chemoperfusion for patients undergoing cytoreductive surgery for peritoneal carcinomatosis of colorectal origin. Conclusions: This recommendation on a standardized delivery of HIPEC in patients with colorectal cancer represents an important first step in enhancing research in this field. Studies directed at maximizing the efficacy of each of the seven key elements will need to follow.

Original languageEnglish (US)
Pages (from-to)1501-1505
Number of pages5
JournalAnnals of surgical oncology
Volume21
Issue number5
DOIs
StatePublished - May 2014
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Oncology

Fingerprint

Dive into the research topics of 'Consensus guidelines from the American Society of Peritoneal Surface Malignancies on standardizing the delivery of hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal cancer patients in the United States'. Together they form a unique fingerprint.

Cite this