Connectomics in Brain Malformations: How Is the Malformed Brain Wired?

Avner Meoded; Thierry A.G.M. Huisman

doi:10.1016/j.nic.2019.03.005

Connectomics in Brain Malformations: How Is the Malformed Brain Wired?

Avner Meoded, Thierry A.G.M. Huisman

Research output: Contribution to journal › Review article › peer-review

Abstract

A new neuroimaging dimension is currently being adopted. The structural connectome reveals macroscale white matter connectivity of the human brain, providing insights into brain networks organization. Connectomics (analysis of the connectome) has potential for elucidating aberrant networks (eg, in congenital brain malformations, especially axonal pathfinding disorders). Connectomics provides a powerful set of network measures, which can serve as noninvasive biomarkers for the diagnosis, prognostication, and treatment response of children. We discuss the principles of connectome reconstruction and visualization of the pediatric structural connectome using current state-of-the-art neuroimaging and postprocessing techniques, and we describe potential connectomics applications to study brain malformations.

Original language	English (US)
Pages (from-to)	435-444
Number of pages	10
Journal	Neuroimaging Clinics of North America
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.nic.2019.03.005
State	Published - Aug 2019
Externally published	Yes

Keywords

Brain
Children
Diffusion tensor imaging
Malformations
Structural connectome

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Clinical Neurology

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10.1016/j.nic.2019.03.005

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title = "Connectomics in Brain Malformations: How Is the Malformed Brain Wired?",

abstract = "A new neuroimaging dimension is currently being adopted. The structural connectome reveals macroscale white matter connectivity of the human brain, providing insights into brain networks organization. Connectomics (analysis of the connectome) has potential for elucidating aberrant networks (eg, in congenital brain malformations, especially axonal pathfinding disorders). Connectomics provides a powerful set of network measures, which can serve as noninvasive biomarkers for the diagnosis, prognostication, and treatment response of children. We discuss the principles of connectome reconstruction and visualization of the pediatric structural connectome using current state-of-the-art neuroimaging and postprocessing techniques, and we describe potential connectomics applications to study brain malformations.",

keywords = "Brain, Children, Diffusion tensor imaging, Malformations, Structural connectome",

author = "Avner Meoded and Huisman, {Thierry A.G.M.}",

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year = "2019",

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AU - Huisman, Thierry A.G.M.

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AB - A new neuroimaging dimension is currently being adopted. The structural connectome reveals macroscale white matter connectivity of the human brain, providing insights into brain networks organization. Connectomics (analysis of the connectome) has potential for elucidating aberrant networks (eg, in congenital brain malformations, especially axonal pathfinding disorders). Connectomics provides a powerful set of network measures, which can serve as noninvasive biomarkers for the diagnosis, prognostication, and treatment response of children. We discuss the principles of connectome reconstruction and visualization of the pediatric structural connectome using current state-of-the-art neuroimaging and postprocessing techniques, and we describe potential connectomics applications to study brain malformations.

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KW - Children

KW - Diffusion tensor imaging

KW - Malformations

KW - Structural connectome

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Connectomics in Brain Malformations: How Is the Malformed Brain Wired?

Abstract

Keywords

ASJC Scopus subject areas

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