Connectomics in Brain Malformations: How Is the Malformed Brain Wired?

Avner Meoded, Thierry A.G.M. Huisman

Research output: Contribution to journalReview articlepeer-review

Abstract

A new neuroimaging dimension is currently being adopted. The structural connectome reveals macroscale white matter connectivity of the human brain, providing insights into brain networks organization. Connectomics (analysis of the connectome) has potential for elucidating aberrant networks (eg, in congenital brain malformations, especially axonal pathfinding disorders). Connectomics provides a powerful set of network measures, which can serve as noninvasive biomarkers for the diagnosis, prognostication, and treatment response of children. We discuss the principles of connectome reconstruction and visualization of the pediatric structural connectome using current state-of-the-art neuroimaging and postprocessing techniques, and we describe potential connectomics applications to study brain malformations.

Original languageEnglish (US)
Pages (from-to)435-444
Number of pages10
JournalNeuroimaging Clinics of North America
Volume29
Issue number3
DOIs
StatePublished - Aug 2019

Keywords

  • Brain
  • Children
  • Diffusion tensor imaging
  • Malformations
  • Structural connectome

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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