Connectome and maturation profiles of the developing mouse brain using diffusion tensor imaging

Madhura Ingalhalikar, Drew Parker, Yasser Ghanbari, Alex Smith, Kegang Hua, Susumu Mori, Ted Abel, Christos Davatzikos, Ragini Verma

Research output: Contribution to journalArticle

Abstract

This paper presents a comprehensive effort to establish a structural mouse connectome using diffusion tensor magnetic resonance imaging coupled with connectivity analysis tools. This work lays the foundation for imaging-based structural connectomics of the mouse brain, potentially facilitating a whole-brain network analysis to quantify brain changes in connectivity during development, as well as deviations from it related to genetic effects. A connectomic trajectory of maturation during postnatal ages 2-80 days is presented in the C57BL/6J mouse strain, using a whole-brain connectivity analysis, followed by investigations based on local and global network features. The global network measures of density, global efficiency, and modularity demonstrated a nonlinear relationship with age. The regional network metrics, namely degree and local efficiency, displayed a differential change in the major subcortical structures such as the thalamus and hippocampus, and cortical regions such as visual and motor cortex. Finally, the connectomes were used to derive an index of "brain connectivity index," which demonstrated a high correlation (r = 0.95) with the chronological age, indicating that brain connectivity is a good marker of normal age progression, hence valuable in detecting subtle deviations from normality caused by genetic, environmental, or pharmacological manipulations.

Original languageEnglish (US)
Pages (from-to)2696-2706
Number of pages11
JournalCerebral Cortex
Volume25
Issue number9
DOIs
StatePublished - Sep 1 2015

Fingerprint

Connectome
Diffusion Tensor Imaging
Brain
Diffusion Magnetic Resonance Imaging
Motor Cortex
Visual Cortex
Thalamus
Inbred C57BL Mouse
Hippocampus
Pharmacology

Keywords

  • Connectome
  • Diffusion tensor imaging
  • Maturation
  • Mouse

ASJC Scopus subject areas

  • Medicine(all)
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Ingalhalikar, M., Parker, D., Ghanbari, Y., Smith, A., Hua, K., Mori, S., ... Verma, R. (2015). Connectome and maturation profiles of the developing mouse brain using diffusion tensor imaging. Cerebral Cortex, 25(9), 2696-2706. https://doi.org/10.1093/cercor/bhu068

Connectome and maturation profiles of the developing mouse brain using diffusion tensor imaging. / Ingalhalikar, Madhura; Parker, Drew; Ghanbari, Yasser; Smith, Alex; Hua, Kegang; Mori, Susumu; Abel, Ted; Davatzikos, Christos; Verma, Ragini.

In: Cerebral Cortex, Vol. 25, No. 9, 01.09.2015, p. 2696-2706.

Research output: Contribution to journalArticle

Ingalhalikar, M, Parker, D, Ghanbari, Y, Smith, A, Hua, K, Mori, S, Abel, T, Davatzikos, C & Verma, R 2015, 'Connectome and maturation profiles of the developing mouse brain using diffusion tensor imaging', Cerebral Cortex, vol. 25, no. 9, pp. 2696-2706. https://doi.org/10.1093/cercor/bhu068
Ingalhalikar, Madhura ; Parker, Drew ; Ghanbari, Yasser ; Smith, Alex ; Hua, Kegang ; Mori, Susumu ; Abel, Ted ; Davatzikos, Christos ; Verma, Ragini. / Connectome and maturation profiles of the developing mouse brain using diffusion tensor imaging. In: Cerebral Cortex. 2015 ; Vol. 25, No. 9. pp. 2696-2706.
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