Connectivity supporting attention in children with attention deficit hyperactivity disorder

Anita D. Barber, Lisa Anne Jacobson, Joanna L. Wexler, Mary Beth Nebel, Brian S Caffo, James J Pekar, Stewart H Mostofsky

Research output: Contribution to journalArticle

Abstract

Intra-subject variability (ISV) is the most consistent behavioral deficit in Attention Deficit Hyperactivity Disorder (ADHD). ISV may be associated with networks involved in sustaining task control (cingulo-opercular network: CON) and self-reflective lapses of attention (default mode network: DMN). The current study examined whether connectivity supporting attentional control is atypical in children with ADHD. Group differences in full-brain connection strength and brain-behavior associations with attentional control measures were examined for the late-developing CON and DMN in 50 children with ADHD and 50 typically-developing (TD) controls (ages 8-12 years). Children with ADHD had hyper-connectivity both within the CON and within the DMN. Full-brain behavioral associations were found for a number of between-network connections. Across both groups, more anti-correlation between DMN and occipital cortex supported better attentional control. However, in the TD group, this brain-behavior association was stronger and occurred for a more extensive set of DMN-occipital connections. Differential support for attentional control between the two groups occurred with a number of CON-DMN connections. For all CON-DMN connections identified, increased between-network anti-correlation was associated with better attentional control for the ADHD group, but worse attentional control in the TD group. A number of between-network connections with the medial frontal cortex, in particular, showed this relationship. Follow-up analyses revealed that these associations were specific to attentional control and were not due to individual differences in working memory, IQ, motor control, age, or scan motion. While CON-DMN anti-correlation is associated with improved attention in ADHD, other circuitry supports improved attention in TD children. Greater CON-DMN anti-correlation supported better attentional control in children with ADHD, but worse attentional control in TD children. On the other hand, greater DMN-occipital anti-correlation supported better attentional control in TD children.

Original languageEnglish (US)
Pages (from-to)68-81
Number of pages14
JournalNeuroImage: Clinical
Volume7
DOIs
StatePublished - 2015

Fingerprint

Attention Deficit Disorder with Hyperactivity
Brain
Occipital Lobe
Frontal Lobe
Short-Term Memory
Individuality

Keywords

  • ADHD
  • Attention
  • Default mode network
  • Intra-subject variability
  • Network
  • Resting-state connectivity

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Cognitive Neuroscience
  • Neurology

Cite this

Connectivity supporting attention in children with attention deficit hyperactivity disorder. / Barber, Anita D.; Jacobson, Lisa Anne; Wexler, Joanna L.; Nebel, Mary Beth; Caffo, Brian S; Pekar, James J; Mostofsky, Stewart H.

In: NeuroImage: Clinical, Vol. 7, 2015, p. 68-81.

Research output: Contribution to journalArticle

@article{fc133d92abc54ecba625e1abad934d45,
title = "Connectivity supporting attention in children with attention deficit hyperactivity disorder",
abstract = "Intra-subject variability (ISV) is the most consistent behavioral deficit in Attention Deficit Hyperactivity Disorder (ADHD). ISV may be associated with networks involved in sustaining task control (cingulo-opercular network: CON) and self-reflective lapses of attention (default mode network: DMN). The current study examined whether connectivity supporting attentional control is atypical in children with ADHD. Group differences in full-brain connection strength and brain-behavior associations with attentional control measures were examined for the late-developing CON and DMN in 50 children with ADHD and 50 typically-developing (TD) controls (ages 8-12 years). Children with ADHD had hyper-connectivity both within the CON and within the DMN. Full-brain behavioral associations were found for a number of between-network connections. Across both groups, more anti-correlation between DMN and occipital cortex supported better attentional control. However, in the TD group, this brain-behavior association was stronger and occurred for a more extensive set of DMN-occipital connections. Differential support for attentional control between the two groups occurred with a number of CON-DMN connections. For all CON-DMN connections identified, increased between-network anti-correlation was associated with better attentional control for the ADHD group, but worse attentional control in the TD group. A number of between-network connections with the medial frontal cortex, in particular, showed this relationship. Follow-up analyses revealed that these associations were specific to attentional control and were not due to individual differences in working memory, IQ, motor control, age, or scan motion. While CON-DMN anti-correlation is associated with improved attention in ADHD, other circuitry supports improved attention in TD children. Greater CON-DMN anti-correlation supported better attentional control in children with ADHD, but worse attentional control in TD children. On the other hand, greater DMN-occipital anti-correlation supported better attentional control in TD children.",
keywords = "ADHD, Attention, Default mode network, Intra-subject variability, Network, Resting-state connectivity",
author = "Barber, {Anita D.} and Jacobson, {Lisa Anne} and Wexler, {Joanna L.} and Nebel, {Mary Beth} and Caffo, {Brian S} and Pekar, {James J} and Mostofsky, {Stewart H}",
year = "2015",
doi = "10.1016/j.nicl.2014.11.011",
language = "English (US)",
volume = "7",
pages = "68--81",
journal = "NeuroImage: Clinical",
issn = "2213-1582",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Connectivity supporting attention in children with attention deficit hyperactivity disorder

AU - Barber, Anita D.

AU - Jacobson, Lisa Anne

AU - Wexler, Joanna L.

AU - Nebel, Mary Beth

AU - Caffo, Brian S

AU - Pekar, James J

AU - Mostofsky, Stewart H

PY - 2015

Y1 - 2015

N2 - Intra-subject variability (ISV) is the most consistent behavioral deficit in Attention Deficit Hyperactivity Disorder (ADHD). ISV may be associated with networks involved in sustaining task control (cingulo-opercular network: CON) and self-reflective lapses of attention (default mode network: DMN). The current study examined whether connectivity supporting attentional control is atypical in children with ADHD. Group differences in full-brain connection strength and brain-behavior associations with attentional control measures were examined for the late-developing CON and DMN in 50 children with ADHD and 50 typically-developing (TD) controls (ages 8-12 years). Children with ADHD had hyper-connectivity both within the CON and within the DMN. Full-brain behavioral associations were found for a number of between-network connections. Across both groups, more anti-correlation between DMN and occipital cortex supported better attentional control. However, in the TD group, this brain-behavior association was stronger and occurred for a more extensive set of DMN-occipital connections. Differential support for attentional control between the two groups occurred with a number of CON-DMN connections. For all CON-DMN connections identified, increased between-network anti-correlation was associated with better attentional control for the ADHD group, but worse attentional control in the TD group. A number of between-network connections with the medial frontal cortex, in particular, showed this relationship. Follow-up analyses revealed that these associations were specific to attentional control and were not due to individual differences in working memory, IQ, motor control, age, or scan motion. While CON-DMN anti-correlation is associated with improved attention in ADHD, other circuitry supports improved attention in TD children. Greater CON-DMN anti-correlation supported better attentional control in children with ADHD, but worse attentional control in TD children. On the other hand, greater DMN-occipital anti-correlation supported better attentional control in TD children.

AB - Intra-subject variability (ISV) is the most consistent behavioral deficit in Attention Deficit Hyperactivity Disorder (ADHD). ISV may be associated with networks involved in sustaining task control (cingulo-opercular network: CON) and self-reflective lapses of attention (default mode network: DMN). The current study examined whether connectivity supporting attentional control is atypical in children with ADHD. Group differences in full-brain connection strength and brain-behavior associations with attentional control measures were examined for the late-developing CON and DMN in 50 children with ADHD and 50 typically-developing (TD) controls (ages 8-12 years). Children with ADHD had hyper-connectivity both within the CON and within the DMN. Full-brain behavioral associations were found for a number of between-network connections. Across both groups, more anti-correlation between DMN and occipital cortex supported better attentional control. However, in the TD group, this brain-behavior association was stronger and occurred for a more extensive set of DMN-occipital connections. Differential support for attentional control between the two groups occurred with a number of CON-DMN connections. For all CON-DMN connections identified, increased between-network anti-correlation was associated with better attentional control for the ADHD group, but worse attentional control in the TD group. A number of between-network connections with the medial frontal cortex, in particular, showed this relationship. Follow-up analyses revealed that these associations were specific to attentional control and were not due to individual differences in working memory, IQ, motor control, age, or scan motion. While CON-DMN anti-correlation is associated with improved attention in ADHD, other circuitry supports improved attention in TD children. Greater CON-DMN anti-correlation supported better attentional control in children with ADHD, but worse attentional control in TD children. On the other hand, greater DMN-occipital anti-correlation supported better attentional control in TD children.

KW - ADHD

KW - Attention

KW - Default mode network

KW - Intra-subject variability

KW - Network

KW - Resting-state connectivity

UR - http://www.scopus.com/inward/record.url?scp=84912550618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84912550618&partnerID=8YFLogxK

U2 - 10.1016/j.nicl.2014.11.011

DO - 10.1016/j.nicl.2014.11.011

M3 - Article

C2 - 25610768

AN - SCOPUS:84912550618

VL - 7

SP - 68

EP - 81

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

SN - 2213-1582

ER -