Connectivity-based analysis: Application to white matter maturation in mouse brain

Youssef Rouchdy, Christos Davatzikos, Ragini Verma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper presents a paradigm for population-based studies using geodesic connectivity maps computed from DTI (Diffusion Tensor Imaging) data. Geodesic connectivity maps provide a measure of connectivity characterization between different regions of the brain using a tensor-based measure that combines anisotropy and orientation information. A connectivity map is constructed relative to a given region in a template space. Population based statistical analysis is then undertaken on these connectivity maps, pertaining to regions of interest. Group-wise changes in these connectivity maps therefore indicate potential disruptions of pathways connecting the ROI with the rest of the brain. This general paradigm for connectivity-based analysis is applied herein to a specific problem, namely the study of white matter maturation in a developing mouse brain, by performing voxel-wise linear regression on connectivity maps computed from several white matter regions. The study shows a significant effect of age whereas no effect of sex is observed.

Original languageEnglish (US)
Title of host publicationProceedings - International Symposium on Biomedical Imaging
Pages54-57
Number of pages4
DOIs
Publication statusPublished - 2012
Externally publishedYes
Event2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Barcelona, Spain
Duration: May 2 2012May 5 2012

Other

Other2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
CountrySpain
CityBarcelona
Period5/2/125/5/12

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Keywords

  • diffusion tensor imaging
  • geodesic connectivity
  • maturation
  • mouse
  • statistics

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Rouchdy, Y., Davatzikos, C., & Verma, R. (2012). Connectivity-based analysis: Application to white matter maturation in mouse brain. In Proceedings - International Symposium on Biomedical Imaging (pp. 54-57). [6235482] https://doi.org/10.1109/ISBI.2012.6235482