Connectivity-based analysis: Application to white matter maturation in mouse brain

Youssef Rouchdy, Christos Davatzikos, Ragini Verma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper presents a paradigm for population-based studies using geodesic connectivity maps computed from DTI (Diffusion Tensor Imaging) data. Geodesic connectivity maps provide a measure of connectivity characterization between different regions of the brain using a tensor-based measure that combines anisotropy and orientation information. A connectivity map is constructed relative to a given region in a template space. Population based statistical analysis is then undertaken on these connectivity maps, pertaining to regions of interest. Group-wise changes in these connectivity maps therefore indicate potential disruptions of pathways connecting the ROI with the rest of the brain. This general paradigm for connectivity-based analysis is applied herein to a specific problem, namely the study of white matter maturation in a developing mouse brain, by performing voxel-wise linear regression on connectivity maps computed from several white matter regions. The study shows a significant effect of age whereas no effect of sex is observed.

Original languageEnglish (US)
Title of host publication2012 9th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2012 - Proceedings
Pages54-57
Number of pages4
DOIs
StatePublished - Aug 15 2012
Event2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Barcelona, Spain
Duration: May 2 2012May 5 2012

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
CountrySpain
CityBarcelona
Period5/2/125/5/12

Keywords

  • diffusion tensor imaging
  • geodesic connectivity
  • maturation
  • mouse
  • statistics

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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