Connecting myokines and metabolism

Rexford S. Ahima, Hyeong Kyu Park

Research output: Contribution to journalReview articlepeer-review


Skeletal muscle is the largest organ of the body in non-obese individuals and is now considered to be an endocrine organ. Hormones (myokines) secreted by skeletal muscle mediate communications between muscle and liver, adipose tissue, brain, and other organs. Myokines affect muscle mass and myofiber switching, and have profound effects on glucose and lipid metabolism and inflammation, thus contributing to energy homeostasis and the pathogenesis of obesity, diabetes, and other diseases. In this review, we summarize recent findings on the biology of myokines and provide an assessment of their potential as therapeutic targets.

Original languageEnglish (US)
Pages (from-to)235-245
Number of pages11
JournalEndocrinology and Metabolism
Issue number3
StatePublished - 2015
Externally publishedYes


  • Diabetes
  • Exercise
  • Metabolism
  • Muscle
  • Myokine
  • Obesity
  • Skeletal

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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