Abstract
To understand further the association between high-level resistance to kanamycin and penicillin tolerance in group A streptococci, high-level resistance to kanamycin was transferred from a penicillin-tolerant group A streptococcal strain possessing a high-level resistance to kanamycin to a penicillin non-tolerant, kanamycin-susceptible group A streptococcal strain and transconjugants were examined for penicillin tolerance. Transfer of high-level resistance to kanamycin occurred at a frequency of 10-6. Transconjugants carrying high-level resistance to kanamycin exhibited characteristics of penicillin tolerance. These findings suggest that the genetic basis for penicillin tolerance is related to that for high-level resistance to kanamycin in group A streptococci. Further studies are needed to characterize the transferable genetic element(s).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 329-333 |
| Number of pages | 5 |
| Journal | FEMS microbiology letters |
| Volume | 57 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 1989 |
| Externally published | Yes |
Keywords
- Conjugative transfer
- Group A streptococcus
- Penicillin tolerance
- high-level resistance to, Kanamycin
ASJC Scopus subject areas
- Microbiology
- Molecular Biology
- Genetics