Conjugative co-transfer of penicillin tolerance and high-level resistance to kanamycin in group A streptococci

T. M. Lakshmi, Sik Kim Kwang Sik Kim

Research output: Contribution to journalArticlepeer-review

Abstract

To understand further the association between high-level resistance to kanamycin and penicillin tolerance in group A streptococci, high-level resistance to kanamycin was transferred from a penicillin-tolerant group A streptococcal strain possessing a high-level resistance to kanamycin to a penicillin non-tolerant, kanamycin-susceptible group A streptococcal strain and transconjugants were examined for penicillin tolerance. Transfer of high-level resistance to kanamycin occurred at a frequency of 10-6. Transconjugants carrying high-level resistance to kanamycin exhibited characteristics of penicillin tolerance. These findings suggest that the genetic basis for penicillin tolerance is related to that for high-level resistance to kanamycin in group A streptococci. Further studies are needed to characterize the transferable genetic element(s).

Original languageEnglish (US)
Pages (from-to)329-333
Number of pages5
JournalFEMS microbiology letters
Volume57
Issue number3
DOIs
StatePublished - Feb 1989
Externally publishedYes

Keywords

  • Conjugative transfer
  • Group A streptococcus
  • Penicillin tolerance
  • high-level resistance to, Kanamycin

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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