Conjugated bisphenol A in maternal serum in relation to miscarriage risk

Ruth B. Lathi, Cara A. Liebert, Kathleen F. Brookfield, Julia A. Taylor, Frederick S. Vom Saal, Victor Y. Fujimoto, Valerie Baker

Research output: Contribution to journalArticle

Abstract

Objective To examine the relationship between the maternal serum bisphenol A (BPA) concentration at the time of the missed menstrual cycle and miscarriage risk. Design Retrospective cohort of prospectively collected serum samples. Setting Academic fertility center. Patient(s) Women presenting for early pregnancy monitoring with singleton pregnancies. Intervention(s) Stored serum samples from 4 to 5 weeks' gestation analyzed for conjugated serum BPA concentrations. Main Outcome Measure(s) Live birth, miscarriage, and chromosome content of miscarriage. Result(s) With the 115 women included in the study, there were 47 live births and 68 clinical miscarriages (46 aneuploid and 22 euploid). Median conjugated BPA concentrations were higher in the women who had miscarriages than in those who had live births (0.101 vs. 0.075 ng/mL). Women with the highest quartile of conjugated BPA had an increased relative risk of miscarriage (1.83; 95% CI, 1.14-2.96) compared with the women in the lowest quartile. We found a similar increase risk for both euploid and aneuploid miscarriages. Conclusion(s) Maternal conjugated BPA was associated with a higher risk of aneuploid and euploid miscarriage in this cohort. The impact of reducing individual exposure on future pregnancy outcomes deserves further study.

Original languageEnglish (US)
Pages (from-to)123-128
Number of pages6
JournalFertility and sterility
Volume102
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Spontaneous Abortion
Mothers
Serum
Live Birth
Aneuploidy
Pregnancy
bisphenol A
Pregnancy Outcome
Menstrual Cycle
Fertility
Chromosomes
Outcome Assessment (Health Care)

Keywords

  • Aneuploidy
  • bisphenol A
  • endocrine disruptor
  • miscarriage
  • pregnancy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Lathi, R. B., Liebert, C. A., Brookfield, K. F., Taylor, J. A., Vom Saal, F. S., Fujimoto, V. Y., & Baker, V. (2014). Conjugated bisphenol A in maternal serum in relation to miscarriage risk. Fertility and sterility, 102(1), 123-128. https://doi.org/10.1016/j.fertnstert.2014.03.024

Conjugated bisphenol A in maternal serum in relation to miscarriage risk. / Lathi, Ruth B.; Liebert, Cara A.; Brookfield, Kathleen F.; Taylor, Julia A.; Vom Saal, Frederick S.; Fujimoto, Victor Y.; Baker, Valerie.

In: Fertility and sterility, Vol. 102, No. 1, 01.01.2014, p. 123-128.

Research output: Contribution to journalArticle

Lathi, RB, Liebert, CA, Brookfield, KF, Taylor, JA, Vom Saal, FS, Fujimoto, VY & Baker, V 2014, 'Conjugated bisphenol A in maternal serum in relation to miscarriage risk', Fertility and sterility, vol. 102, no. 1, pp. 123-128. https://doi.org/10.1016/j.fertnstert.2014.03.024
Lathi RB, Liebert CA, Brookfield KF, Taylor JA, Vom Saal FS, Fujimoto VY et al. Conjugated bisphenol A in maternal serum in relation to miscarriage risk. Fertility and sterility. 2014 Jan 1;102(1):123-128. https://doi.org/10.1016/j.fertnstert.2014.03.024
Lathi, Ruth B. ; Liebert, Cara A. ; Brookfield, Kathleen F. ; Taylor, Julia A. ; Vom Saal, Frederick S. ; Fujimoto, Victor Y. ; Baker, Valerie. / Conjugated bisphenol A in maternal serum in relation to miscarriage risk. In: Fertility and sterility. 2014 ; Vol. 102, No. 1. pp. 123-128.
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