TY - JOUR
T1 - Congenital renal agenesis
T2 - Case-control analysis of birth characteristics
AU - Parikh, Chirag R.
AU - McCall, Daniel
AU - Engelman, Corinne
AU - Schrier, Robert W.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2002
Y1 - 2002
N2 - • Renal agenesis (RA) is the most common congenital urinary malformation; however, evidence for prenatal factors associated with the development of this condition is limited. The aim of this study is to determine prenatal and perinatal factors associated with the development of RA. We performed a case-control study of Colorado births with RA from 1989 to 1998 identified in the Colorado Responds for Children With Special Needs and linked with birth certificate data. There were 189 infants with RA and 940 control infants without RA on the study. The incidence of RA is approximately 1 per 2,900 births. Seventy-six infants (40.6%) born with RA were girls, and 111 infants (59.4%) were boys (P = 0.02). Preexisting diabetes mellitus in the mother was a significant factor associated with RA (adjusted odds ratio (OR), 4.98; 95% confidence interval (Cl), 1.08 to 22.93) while controlling for maternal age, maternal race, and alcohol exposure. Black maternal race also was significantly associated with the development of RA (adjusted OR, 2.19; 95% Cl, 1.26 to 3.95) while controlling for other factors. Maternal age younger than 18 years, maternal education less than 12 years, alcohol exposure, and infant sex approached significance. RA is a relatively common congenital malformation of the urinary tract. This condition appears to have a multifactorial cause, with a combination of genetic and environmental factors. Further research is needed to show a better understanding of these risk factors.
AB - • Renal agenesis (RA) is the most common congenital urinary malformation; however, evidence for prenatal factors associated with the development of this condition is limited. The aim of this study is to determine prenatal and perinatal factors associated with the development of RA. We performed a case-control study of Colorado births with RA from 1989 to 1998 identified in the Colorado Responds for Children With Special Needs and linked with birth certificate data. There were 189 infants with RA and 940 control infants without RA on the study. The incidence of RA is approximately 1 per 2,900 births. Seventy-six infants (40.6%) born with RA were girls, and 111 infants (59.4%) were boys (P = 0.02). Preexisting diabetes mellitus in the mother was a significant factor associated with RA (adjusted odds ratio (OR), 4.98; 95% confidence interval (Cl), 1.08 to 22.93) while controlling for maternal age, maternal race, and alcohol exposure. Black maternal race also was significantly associated with the development of RA (adjusted OR, 2.19; 95% Cl, 1.26 to 3.95) while controlling for other factors. Maternal age younger than 18 years, maternal education less than 12 years, alcohol exposure, and infant sex approached significance. RA is a relatively common congenital malformation of the urinary tract. This condition appears to have a multifactorial cause, with a combination of genetic and environmental factors. Further research is needed to show a better understanding of these risk factors.
KW - Birth certificate
KW - Case-control study
KW - Congenital renal agenesis (RA)
KW - Risk factors
KW - Solitary kidney
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U2 - 10.1053/ajkd.2002.31982
DO - 10.1053/ajkd.2002.31982
M3 - Article
C2 - 11920333
AN - SCOPUS:0036198288
SN - 0272-6386
VL - 39
SP - 689
EP - 694
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 4
ER -