Congenital platelet disorder and type I von Willebrand disease presenting as prolonged bleeding after cleft lip and palate repair

John Pang, Jonathan Zelken, Amir H. Dorafshar, John J. Strouse, Richard Redett

Research output: Contribution to journalArticlepeer-review

Abstract

Cleft lip and palate can be associated with coagulopathy. Here, we report the first known case of congenital platelet disorder and von Willebrand disease presenting as prolonged bleeding after cleft lip and palate repair. After identifying the underlying pathology, platelet infusions and aminocaproic acid were given to decrease bleeding from a second surgical procedure. Whole exome sequencing identified a von Willebrand factor gene mutation, an adenine to guanine substitution at the c.475A location. A high index of suspicion should be had for coagulopathy in patients with syndromic cleft lip and palate.

Original languageEnglish (US)
Pages (from-to)740-742
Number of pages3
JournalCleft Palate-Craniofacial Journal
Volume51
Issue number6
DOIs
StatePublished - Nov 1 2014

Keywords

  • Cleft lip
  • Cleft palate
  • Platelet abnormality
  • Von Willebrand disease

ASJC Scopus subject areas

  • Oral Surgery
  • Otorhinolaryngology

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