TY - JOUR
T1 - Congenital malformations and psychosocial development in children conceived by in vitro fertilization
AU - Morin, Norma C.
AU - Wirth, Frederick H.
AU - Johnson, David H.
AU - Frank, L. Matthew
AU - Presburg, Harry J.
AU - Van de Water, Virginia L.
AU - Chee, Elsbeth M.
AU - Mills, James L.
N1 - Funding Information:
From Eastern Virginia Medical School and Children's Hospital of the King's Daughters, Norfolk, Virginia; The Johns Hopkins University School of Hygiene and Public Health, Baltimore; and Prevention Research Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
PY - 1989/8
Y1 - 1989/8
N2 - To determine whether in vitro fertilization (IVF) as a method of conception is associated with an increased risk for congenital malformations or developmental dysfunction, we performed a general physical examination for malformations, neurologic examination, developmental examination (Bayley Scales), echocardiography, electrocardiography, abdominal ultrasound study, and, when possible, cranial ultrasound examination on a cohort of 83 IVF children and 93 matched non-IVF children. Major malformations were found in two IVF and one non-IVF subject; the rates were not significantly different. The mean Mental Development Index scores for IVF subjects and the comparison group were 115±13 and 111±13, respectively (p=0.12). The mean Psychomotor Development Index scores were 114±14 and 108±15 (p=0.04). Based on these small numbers but extensive evaluation, we found no association between conception by IVF and an increased risk for congenital malformations. Likewise, children conceived by IVF showed no evidence of developmental delay. Their high average achievement on the Bayley tests probably resulted from the exceptional motivation of their parents ("wantedness") and their generally high socioeconomic status.
AB - To determine whether in vitro fertilization (IVF) as a method of conception is associated with an increased risk for congenital malformations or developmental dysfunction, we performed a general physical examination for malformations, neurologic examination, developmental examination (Bayley Scales), echocardiography, electrocardiography, abdominal ultrasound study, and, when possible, cranial ultrasound examination on a cohort of 83 IVF children and 93 matched non-IVF children. Major malformations were found in two IVF and one non-IVF subject; the rates were not significantly different. The mean Mental Development Index scores for IVF subjects and the comparison group were 115±13 and 111±13, respectively (p=0.12). The mean Psychomotor Development Index scores were 114±14 and 108±15 (p=0.04). Based on these small numbers but extensive evaluation, we found no association between conception by IVF and an increased risk for congenital malformations. Likewise, children conceived by IVF showed no evidence of developmental delay. Their high average achievement on the Bayley tests probably resulted from the exceptional motivation of their parents ("wantedness") and their generally high socioeconomic status.
UR - http://www.scopus.com/inward/record.url?scp=0024356598&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024356598&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(89)80069-1
DO - 10.1016/S0022-3476(89)80069-1
M3 - Article
C2 - 2666626
AN - SCOPUS:0024356598
SN - 0022-3476
VL - 115
SP - 222
EP - 227
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 2
ER -