Congenital and perinatal infections: Throwing new light with an old TORCH

Research output: Contribution to journalArticle

Abstract

Infections acquired in utero or in the immediate post-natal period play a prominent role in perinatal and childhood morbidity. The TORCH constellation continues to be popular among perinatologists and paediatricians, although its limitations are increasingly known. A host of new organisms are now considered to be perpetrators of congenital and perinatal infections, and a diverse range of diagnostic tests are now available for confirming infection in the infant. In general, the collective TORCH serological panel has low diagnostic yield; instead individual tests ordered according to clinical presentation can contribute better towards appropriate diagnosis. This review captures the essence of established congenital infections such as cytomegalovirus, rubella, toxoplasmosis, syphilis and herpes simplex virus, as well as more recent entrants such as HIV and hepatitis B infection, varicella and tuberculosis. Selective screening of the mother and newborn, encouraging good personal hygiene and universal immunization are some measures that can contribute towards decreasing the incidence and morbidity of congenital and perinatal infections.

Original languageEnglish (US)
Pages (from-to)88-95
Number of pages8
JournalIndian Journal of Pediatrics
Volume78
Issue number1
DOIs
StatePublished - Jan 2011
Externally publishedYes

Fingerprint

Infection
Morbidity
Chickenpox
Rubella
Toxoplasmosis
Simplexvirus
Syphilis
Hepatitis B
Hygiene
Cytomegalovirus
Routine Diagnostic Tests
Immunization
Tuberculosis
Mothers
HIV
Newborn Infant
Incidence

Keywords

  • Congenital infections
  • Infants
  • Perinatal
  • TORCH

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Congenital and perinatal infections : Throwing new light with an old TORCH. / Shet, Anita.

In: Indian Journal of Pediatrics, Vol. 78, No. 1, 01.2011, p. 88-95.

Research output: Contribution to journalArticle

@article{1dfdde3e136e480fa316b99cea78013b,
title = "Congenital and perinatal infections: Throwing new light with an old TORCH",
abstract = "Infections acquired in utero or in the immediate post-natal period play a prominent role in perinatal and childhood morbidity. The TORCH constellation continues to be popular among perinatologists and paediatricians, although its limitations are increasingly known. A host of new organisms are now considered to be perpetrators of congenital and perinatal infections, and a diverse range of diagnostic tests are now available for confirming infection in the infant. In general, the collective TORCH serological panel has low diagnostic yield; instead individual tests ordered according to clinical presentation can contribute better towards appropriate diagnosis. This review captures the essence of established congenital infections such as cytomegalovirus, rubella, toxoplasmosis, syphilis and herpes simplex virus, as well as more recent entrants such as HIV and hepatitis B infection, varicella and tuberculosis. Selective screening of the mother and newborn, encouraging good personal hygiene and universal immunization are some measures that can contribute towards decreasing the incidence and morbidity of congenital and perinatal infections.",
keywords = "Congenital infections, Infants, Perinatal, TORCH",
author = "Anita Shet",
year = "2011",
month = "1",
doi = "10.1007/s12098-010-0254-3",
language = "English (US)",
volume = "78",
pages = "88--95",
journal = "Indian Journal of Practical Pediatrics",
issn = "0972-9607",
publisher = "Springer India",
number = "1",

}

TY - JOUR

T1 - Congenital and perinatal infections

T2 - Throwing new light with an old TORCH

AU - Shet, Anita

PY - 2011/1

Y1 - 2011/1

N2 - Infections acquired in utero or in the immediate post-natal period play a prominent role in perinatal and childhood morbidity. The TORCH constellation continues to be popular among perinatologists and paediatricians, although its limitations are increasingly known. A host of new organisms are now considered to be perpetrators of congenital and perinatal infections, and a diverse range of diagnostic tests are now available for confirming infection in the infant. In general, the collective TORCH serological panel has low diagnostic yield; instead individual tests ordered according to clinical presentation can contribute better towards appropriate diagnosis. This review captures the essence of established congenital infections such as cytomegalovirus, rubella, toxoplasmosis, syphilis and herpes simplex virus, as well as more recent entrants such as HIV and hepatitis B infection, varicella and tuberculosis. Selective screening of the mother and newborn, encouraging good personal hygiene and universal immunization are some measures that can contribute towards decreasing the incidence and morbidity of congenital and perinatal infections.

AB - Infections acquired in utero or in the immediate post-natal period play a prominent role in perinatal and childhood morbidity. The TORCH constellation continues to be popular among perinatologists and paediatricians, although its limitations are increasingly known. A host of new organisms are now considered to be perpetrators of congenital and perinatal infections, and a diverse range of diagnostic tests are now available for confirming infection in the infant. In general, the collective TORCH serological panel has low diagnostic yield; instead individual tests ordered according to clinical presentation can contribute better towards appropriate diagnosis. This review captures the essence of established congenital infections such as cytomegalovirus, rubella, toxoplasmosis, syphilis and herpes simplex virus, as well as more recent entrants such as HIV and hepatitis B infection, varicella and tuberculosis. Selective screening of the mother and newborn, encouraging good personal hygiene and universal immunization are some measures that can contribute towards decreasing the incidence and morbidity of congenital and perinatal infections.

KW - Congenital infections

KW - Infants

KW - Perinatal

KW - TORCH

UR - http://www.scopus.com/inward/record.url?scp=78751615954&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78751615954&partnerID=8YFLogxK

U2 - 10.1007/s12098-010-0254-3

DO - 10.1007/s12098-010-0254-3

M3 - Article

C2 - 20953849

AN - SCOPUS:78751615954

VL - 78

SP - 88

EP - 95

JO - Indian Journal of Practical Pediatrics

JF - Indian Journal of Practical Pediatrics

SN - 0972-9607

IS - 1

ER -