SMAP29, an ovine cathelicidin, was systematically altered to create a family of 23 related peptides for MIC and minimum bactericidal concentration determinations. SMAP28, SMAP29, and a derivative of SMAP29 called ovispirin were all antimicrobial. However, many congeners of SMAP29 and ovispirin were not as active as the parent molecules. With immunoelectron microscopy, SMAP29 was seen on membranes and within the cytoplasm of Pseudomonas aeruginosa PAO1.
|Original language||English (US)|
|Number of pages||6|
|Journal||Antimicrobial agents and chemotherapy|
|State||Published - 2001|
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases