Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells

V. C. Kalfa; H. P. Jia; R. A. Kunkle; Jr McCray; B. F. Tack; K. A. Brogden

doi:10.1128/AAC.45.11.3256-3261.2001

Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells

V. C. Kalfa, H. P. Jia, R. A. Kunkle, Jr McCray, B. F. Tack, K. A. Brogden

Research output: Contribution to journal › Article › peer-review

Abstract

SMAP29, an ovine cathelicidin, was systematically altered to create a family of 23 related peptides for MIC and minimum bactericidal concentration determinations. SMAP28, SMAP29, and a derivative of SMAP29 called ovispirin were all antimicrobial. However, many congeners of SMAP29 and ovispirin were not as active as the parent molecules. With immunoelectron microscopy, SMAP29 was seen on membranes and within the cytoplasm of Pseudomonas aeruginosa PAO1.

Original language	English (US)
Pages (from-to)	3256-3261
Number of pages	6
Journal	Antimicrobial agents and chemotherapy
Volume	45
Issue number	11
DOIs	https://doi.org/10.1128/AAC.45.11.3256-3261.2001
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

Access to Document

10.1128/AAC.45.11.3256-3261.2001

Cite this

@article{4bfc47031e2341629bb3bf5109863d11,

title = "Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells",

abstract = "SMAP29, an ovine cathelicidin, was systematically altered to create a family of 23 related peptides for MIC and minimum bactericidal concentration determinations. SMAP28, SMAP29, and a derivative of SMAP29 called ovispirin were all antimicrobial. However, many congeners of SMAP29 and ovispirin were not as active as the parent molecules. With immunoelectron microscopy, SMAP29 was seen on membranes and within the cytoplasm of Pseudomonas aeruginosa PAO1.",

author = "Kalfa, {V. C.} and Jia, {H. P.} and Kunkle, {R. A.} and Jr McCray and Tack, {B. F.} and Brogden, {K. A.}",

year = "2001",

doi = "10.1128/AAC.45.11.3256-3261.2001",

language = "English (US)",

volume = "45",

pages = "3256--3261",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "11",

}

TY - JOUR

T1 - Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells

AU - Kalfa, V. C.

AU - Jia, H. P.

AU - Kunkle, R. A.

AU - McCray, Jr

AU - Tack, B. F.

AU - Brogden, K. A.

PY - 2001

Y1 - 2001

N2 - SMAP29, an ovine cathelicidin, was systematically altered to create a family of 23 related peptides for MIC and minimum bactericidal concentration determinations. SMAP28, SMAP29, and a derivative of SMAP29 called ovispirin were all antimicrobial. However, many congeners of SMAP29 and ovispirin were not as active as the parent molecules. With immunoelectron microscopy, SMAP29 was seen on membranes and within the cytoplasm of Pseudomonas aeruginosa PAO1.

AB - SMAP29, an ovine cathelicidin, was systematically altered to create a family of 23 related peptides for MIC and minimum bactericidal concentration determinations. SMAP28, SMAP29, and a derivative of SMAP29 called ovispirin were all antimicrobial. However, many congeners of SMAP29 and ovispirin were not as active as the parent molecules. With immunoelectron microscopy, SMAP29 was seen on membranes and within the cytoplasm of Pseudomonas aeruginosa PAO1.

UR - http://www.scopus.com/inward/record.url?scp=0034775147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034775147&partnerID=8YFLogxK

U2 - 10.1128/AAC.45.11.3256-3261.2001

DO - 10.1128/AAC.45.11.3256-3261.2001

M3 - Article

C2 - 11600395

AN - SCOPUS:0034775147

SN - 0066-4804

VL - 45

SP - 3256

EP - 3261

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 11

ER -

Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this