Confirmatory factor analysis of the ADNI neuropsychological battery

Lovingly Quitania Park, Alden L Gross, Donald G. McLaren, Judy Pa, Julene K. Johnson, Meghan Mitchell, Jennifer J. Manly

Research output: Contribution to journalArticle

Abstract

The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a large multi-center study designed to develop optimized methods for acquiring longitudinal neuroimaging, cognitive, and biomarker measures of AD progression in a large cohort of patients with Alzheimer's disease (AD), patients with Mild Cognitive Impairment, and healthy controls. Detailed neuropsychological testing was conducted on all participants. We examined the factor structure of the ADNI Neuropsychological Battery across older adults with differing levels of clinical AD severity based on the Clinical Dementia Rating Scale (CDR). Confirmatory factor analysis (CFA) of 23 variables from 10 neuropsychological tests resulted in five factors (memory, language, visuospatial functioning, attention, and executive function/processing speed) that were invariant across levels of cognitive impairment. Thus, these five factors can be used as indicators of cognitive function in older adults who are participants in ADNI.

Original languageEnglish (US)
Pages (from-to)528-539
Number of pages12
JournalBrain Imaging and Behavior
Volume6
Issue number4
DOIs
StatePublished - 2012
Externally publishedYes

Fingerprint

Neuroimaging
Statistical Factor Analysis
Alzheimer Disease
Neuropsychological Tests
Executive Function
Cognition
Dementia
Disease Progression
Language
Biomarkers
Cognitive Dysfunction

Keywords

  • ADNI
  • Cognition
  • Cognitive change
  • Confirmatory factor analysis
  • Neuropsychology

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Behavioral Neuroscience
  • Radiology Nuclear Medicine and imaging

Cite this

Park, L. Q., Gross, A. L., McLaren, D. G., Pa, J., Johnson, J. K., Mitchell, M., & Manly, J. J. (2012). Confirmatory factor analysis of the ADNI neuropsychological battery. Brain Imaging and Behavior, 6(4), 528-539. https://doi.org/10.1007/s11682-012-9190-3

Confirmatory factor analysis of the ADNI neuropsychological battery. / Park, Lovingly Quitania; Gross, Alden L; McLaren, Donald G.; Pa, Judy; Johnson, Julene K.; Mitchell, Meghan; Manly, Jennifer J.

In: Brain Imaging and Behavior, Vol. 6, No. 4, 2012, p. 528-539.

Research output: Contribution to journalArticle

Park, LQ, Gross, AL, McLaren, DG, Pa, J, Johnson, JK, Mitchell, M & Manly, JJ 2012, 'Confirmatory factor analysis of the ADNI neuropsychological battery', Brain Imaging and Behavior, vol. 6, no. 4, pp. 528-539. https://doi.org/10.1007/s11682-012-9190-3
Park, Lovingly Quitania ; Gross, Alden L ; McLaren, Donald G. ; Pa, Judy ; Johnson, Julene K. ; Mitchell, Meghan ; Manly, Jennifer J. / Confirmatory factor analysis of the ADNI neuropsychological battery. In: Brain Imaging and Behavior. 2012 ; Vol. 6, No. 4. pp. 528-539.
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