Confirmatory factor analysis of the ADNI neuropsychological battery

Lovingly Quitania Park, Alden L. Gross, Donald G. McLaren, Judy Pa, Julene K. Johnson, Meghan Mitchell, Jennifer J. Manly

Research output: Contribution to journalArticlepeer-review

Abstract

The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a large multi-center study designed to develop optimized methods for acquiring longitudinal neuroimaging, cognitive, and biomarker measures of AD progression in a large cohort of patients with Alzheimer's disease (AD), patients with Mild Cognitive Impairment, and healthy controls. Detailed neuropsychological testing was conducted on all participants. We examined the factor structure of the ADNI Neuropsychological Battery across older adults with differing levels of clinical AD severity based on the Clinical Dementia Rating Scale (CDR). Confirmatory factor analysis (CFA) of 23 variables from 10 neuropsychological tests resulted in five factors (memory, language, visuospatial functioning, attention, and executive function/processing speed) that were invariant across levels of cognitive impairment. Thus, these five factors can be used as indicators of cognitive function in older adults who are participants in ADNI.

Original languageEnglish (US)
Pages (from-to)528-539
Number of pages12
JournalBrain Imaging and Behavior
Volume6
Issue number4
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • ADNI
  • Cognition
  • Cognitive change
  • Confirmatory factor analysis
  • Neuropsychology

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

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