Abstract
The presence of cocaine was confirmed in the saliva of two male human subjects who had received intravenous doses of cocaine. For one subject, the saliva:plasma concentration ratios varied from 2.96 to 0.5 over time following drug administration. Correlations of saliva to plasma cocaine levels were highly significant (p ` 0.001) across doses of 15, 20, and 40 mg of intravenously administered cocaine. These findings are important in that they allow monitoring blood levels of cocaine after intravenous infusion in a non-invasive manner, and could form the basis for development of a non-invasive screen for active cocaine levels in saliva.
Original language | English (US) |
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Pages (from-to) | 36-38 |
Number of pages | 3 |
Journal | Journal of analytical toxicology |
Volume | 11 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 1987 |
Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Environmental Chemistry
- Toxicology
- Health, Toxicology and Mutagenesis
- Chemical Health and Safety