Clinical health informatics is a new innovation in healthcare systems to transform paper-based systems to electronic systems. Health information is enhancing care coordination, quality and efficiency, but there are concerns related to protecting security and confidentiality of data. The main aspect of using a different electronic package in hospitals depends on important factors such as confidentiality, integrity and availability of health data. This paper is an integrative review of the evidence to compare the Confidentiality, Integrity and Availability (CIA) model in different Electronic Health Records  and identify the contributing factors in selecting different vendors in hospitals. The Johns Hopkins Nursing Evidence-Based Practice model was used to appraise the quality of studies related to health informatics. Forty-five titles were reviewed and, after reviewing 27 abstracts and contents, seven papers were included in this study. According to the reviewed evidence, a health information framework includes “Confidentiality, Integrity and Availability Triad, MEDITECH, Cerner and EPIC were the most popular hospital software packages because of being user-friendly, accessibility, lower cost and high security.