TY - GEN
T1 - Conditions that Influence Nanoparticle Size and Yield in Nanoparticle Preparation
AU - Qiu, Jinghan
AU - Fu, Jie
N1 - Publisher Copyright:
© 2020 ACM.
PY - 2020/9/15
Y1 - 2020/9/15
N2 - In recent years, there is an increased interest in nanoparticles' usage in cancer therapies to facilitate drug delivery. Compared to conventional drug delivery systems, drug delivery that uses nanoparticles as delivery vehicles is more precise at targeting sites and has a higher drug loading. Therefore, when synthesizing nanoparticles for drug delivery, it's important to consider the particles' size and the particles gained after synthesis to ensure the quality and benefits of the nanoparticles. In this research, we have compared the sizes and yield of nanoparticles which are made with variable conditions and investigated if and how different synthesis conditions may cause differences in nanoparticle size and yield. We concluded that PEG-PLGA (polyethylene glycolpoly lactic-co-glycolic acid) polymer results in smaller and less nanoparticles than PLGA2A polymer; with polyvinyl alcohol (PVA, PH=6.8) as the emulsifier, nanoparticles are larger and less compared to those made with phosphate buffered saline (PBS, PH=7.4); when the drug is dissolved in the organic solution ethyl acetate (ETAC), the yielded nanoparticles are much smaller but also has a lighter weight than those with dissolved drug in Dichloromethane (CH2Cl2); with less solution for emulsion, nanoparticles gained more weight and have a smaller size; and for particles made with PEG (25%)-PLA and with Benzyl Alcohol added, the resulting size and yield are both larger.
AB - In recent years, there is an increased interest in nanoparticles' usage in cancer therapies to facilitate drug delivery. Compared to conventional drug delivery systems, drug delivery that uses nanoparticles as delivery vehicles is more precise at targeting sites and has a higher drug loading. Therefore, when synthesizing nanoparticles for drug delivery, it's important to consider the particles' size and the particles gained after synthesis to ensure the quality and benefits of the nanoparticles. In this research, we have compared the sizes and yield of nanoparticles which are made with variable conditions and investigated if and how different synthesis conditions may cause differences in nanoparticle size and yield. We concluded that PEG-PLGA (polyethylene glycolpoly lactic-co-glycolic acid) polymer results in smaller and less nanoparticles than PLGA2A polymer; with polyvinyl alcohol (PVA, PH=6.8) as the emulsifier, nanoparticles are larger and less compared to those made with phosphate buffered saline (PBS, PH=7.4); when the drug is dissolved in the organic solution ethyl acetate (ETAC), the yielded nanoparticles are much smaller but also has a lighter weight than those with dissolved drug in Dichloromethane (CH2Cl2); with less solution for emulsion, nanoparticles gained more weight and have a smaller size; and for particles made with PEG (25%)-PLA and with Benzyl Alcohol added, the resulting size and yield are both larger.
KW - Cancer therapy
KW - Drug delivery
KW - Nanoparticle size
KW - Nanoparticle synthesis
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U2 - 10.1145/3397391.3397419
DO - 10.1145/3397391.3397419
M3 - Conference contribution
AN - SCOPUS:85088160963
T3 - ACM International Conference Proceeding Series
SP - 184
EP - 188
BT - Proceedings of the 2020 10th International Conference on Biomedical Engineering and Technology, ICBET 2020
PB - Association for Computing Machinery
T2 - 10th International Conference on Biomedical Engineering and Technology, ICBET 2020
Y2 - 15 September 2020 through 18 September 2020
ER -