Conditions for vasodilator-induced coronary steal in experimental myocardial ischemia

Research output: Contribution to journalArticle

Abstract

The conditions for coronary steal were determined using the two vasodilators - dipyridamole and nitroglycerin - in anesthetized dogs after ligation of the left anterior descending coronary artery (LAD). Previous studies have shown that when the nonligated coronary arteries are normal, collateral flow increases after dipyridamole. This study utilized a model in which the distal LAD was ligated and the proximal LAD and left circumflex (LC) arteries were stenosed. Heart rate and blood pressure were kept constant. In 20 dogs, 1-1.5 mg/kg dipyridamole caused a decrease in flow to the ischemic region as measured by radioactive microspheres (0.19 to 0.14 ml/min/g, P = 0.05) while flow increased four-fold to surrounding nonischemic myocardium. The decrease in collateral flow was confined to the epicardial half of the ischemic region (0.26 to 0.14 ml/min/g, P

Original languageEnglish (US)
Pages (from-to)1103-1110
Number of pages8
JournalCirculation
Volume57
Issue number6
StatePublished - 1978

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Dipyridamole
Vasodilator Agents
Myocardial Ischemia
Coronary Vessels
Dogs
Nitroglycerin
Microspheres
Ligation
Myocardium
Arteries
Heart Rate
Blood Pressure

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Conditions for vasodilator-induced coronary steal in experimental myocardial ischemia. / Becker, Lewis.

In: Circulation, Vol. 57, No. 6, 1978, p. 1103-1110.

Research output: Contribution to journalArticle

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