Conditioning neoadjuvant therapies for improved immunotherapy of cancer

Zachary Benson, Saeed H. Manjili, Mehran Habibi, Georgi Guruli, Amir A. Toor, Kyle K. Payne, Masoud H. Manjili

Research output: Contribution to journalReview article

Abstract

Recent advances in the treatment of melanoma and non-small cell lung cancer (NSCLC) by combining conventional therapies with anti-PD1/PD-L1 immunotherapies, have renewed interests in immunotherapy of cancer. The emerging concept of conventional cancer therapies combined with immunotherapy differs from the classical concept in that it is not simply taking advantage of their additive anti-tumor effects, but it is to use certain therapeutic regimens to condition the tumor microenvironment for optimal response to immunotherapy. To this end, low dose immunogenic chemotherapies, epigenetic modulators and inhibitors of cell cycle progression are potential candidates for rendering tumors highly responsive to immunotherapy. Next generation immunotherapeutics are therefore predicted to be highly effective against cancer, when they are used following appropriate immune modulatory compounds or targeted delivery of tumor cell cycle inhibitors using nanotechnology.

Original languageEnglish (US)
Pages (from-to)12-17
Number of pages6
JournalBiochemical Pharmacology
Volume145
DOIs
StatePublished - Dec 1 2017

Keywords

  • Cancer immunotherapy
  • Nanoparticles
  • Neoadjuvant therapy
  • Targeted drug delivery

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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  • Cite this

    Benson, Z., Manjili, S. H., Habibi, M., Guruli, G., Toor, A. A., Payne, K. K., & Manjili, M. H. (2017). Conditioning neoadjuvant therapies for improved immunotherapy of cancer. Biochemical Pharmacology, 145, 12-17. https://doi.org/10.1016/j.bcp.2017.08.007