Conditioned taste aversion learning: Implications for animal models of drug abuse

Catherine Davis-Takacs, Anthony L. Riley

Research output: Contribution to journalArticle

Abstract

Drugs of abuse are typically discussed in terms of their rewarding effects and how these effects mediate drug taking. However, these drugs produce aversive effects that could have an important role in the overall acceptability of a drug and its likelihood of being self-administered. Rewarding and aversive effects, then, could be interpreted as separate behavioral effects, with the balance of the two determining overall drug acceptability. Interestingly, the role of aversive effects on drug acceptability in the self-administration preparation has received limited attention in this context. This chapter examines the aversive effects of drugs and discusses their role in drug taking. If these aversive effects serve a protective function, manipulations that alter or decrease these effects could have implications for drug taking. Several factors have been reported to alter conditioned taste aversion (CTA) learning, a preparation used in the assessment of the aversive effects of drugs in general. Two of these factors, drug history and strain, are reviewed here. By reviewing these, we intend to demonstrate the protective nature of aversive effects in the initiation and escalation of drug taking and to provide evidence that reductions in aversive effects could produce changes in patterns of drug self-administration that could lead to an increased vulnerability to abuse drugs by altering the reward-aversion balance. The aim of this chapter is not to question the importance of rewarding effects in self-administration but rather to provide evidence that aversive effects are an important factor that needs to be considered in discussions of drug-taking behavior.

Original languageEnglish (US)
Pages (from-to)247-275
Number of pages29
JournalAnnals of the New York Academy of Sciences
Volume1187
DOIs
StatePublished - Feb 2010
Externally publishedYes

Fingerprint

Substance-Related Disorders
Animals
Animal Models
Learning
Pharmaceutical Preparations
Self Administration
Animal Model
Abuse
Drugs
Aversion
Street Drugs
Reward
History

Keywords

  • Animal models
  • Aversion
  • Conditioned taste aversion
  • Drug abuse
  • Reward

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Conditioned taste aversion learning : Implications for animal models of drug abuse. / Davis-Takacs, Catherine; Riley, Anthony L.

In: Annals of the New York Academy of Sciences, Vol. 1187, 02.2010, p. 247-275.

Research output: Contribution to journalArticle

@article{e7fb6ce77b6b4f418448a4ef8f690aa4,
title = "Conditioned taste aversion learning: Implications for animal models of drug abuse",
abstract = "Drugs of abuse are typically discussed in terms of their rewarding effects and how these effects mediate drug taking. However, these drugs produce aversive effects that could have an important role in the overall acceptability of a drug and its likelihood of being self-administered. Rewarding and aversive effects, then, could be interpreted as separate behavioral effects, with the balance of the two determining overall drug acceptability. Interestingly, the role of aversive effects on drug acceptability in the self-administration preparation has received limited attention in this context. This chapter examines the aversive effects of drugs and discusses their role in drug taking. If these aversive effects serve a protective function, manipulations that alter or decrease these effects could have implications for drug taking. Several factors have been reported to alter conditioned taste aversion (CTA) learning, a preparation used in the assessment of the aversive effects of drugs in general. Two of these factors, drug history and strain, are reviewed here. By reviewing these, we intend to demonstrate the protective nature of aversive effects in the initiation and escalation of drug taking and to provide evidence that reductions in aversive effects could produce changes in patterns of drug self-administration that could lead to an increased vulnerability to abuse drugs by altering the reward-aversion balance. The aim of this chapter is not to question the importance of rewarding effects in self-administration but rather to provide evidence that aversive effects are an important factor that needs to be considered in discussions of drug-taking behavior.",
keywords = "Animal models, Aversion, Conditioned taste aversion, Drug abuse, Reward",
author = "Catherine Davis-Takacs and Riley, {Anthony L.}",
year = "2010",
month = "2",
doi = "10.1111/j.1749-6632.2009.05147.x",
language = "English (US)",
volume = "1187",
pages = "247--275",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Conditioned taste aversion learning

T2 - Implications for animal models of drug abuse

AU - Davis-Takacs, Catherine

AU - Riley, Anthony L.

PY - 2010/2

Y1 - 2010/2

N2 - Drugs of abuse are typically discussed in terms of their rewarding effects and how these effects mediate drug taking. However, these drugs produce aversive effects that could have an important role in the overall acceptability of a drug and its likelihood of being self-administered. Rewarding and aversive effects, then, could be interpreted as separate behavioral effects, with the balance of the two determining overall drug acceptability. Interestingly, the role of aversive effects on drug acceptability in the self-administration preparation has received limited attention in this context. This chapter examines the aversive effects of drugs and discusses their role in drug taking. If these aversive effects serve a protective function, manipulations that alter or decrease these effects could have implications for drug taking. Several factors have been reported to alter conditioned taste aversion (CTA) learning, a preparation used in the assessment of the aversive effects of drugs in general. Two of these factors, drug history and strain, are reviewed here. By reviewing these, we intend to demonstrate the protective nature of aversive effects in the initiation and escalation of drug taking and to provide evidence that reductions in aversive effects could produce changes in patterns of drug self-administration that could lead to an increased vulnerability to abuse drugs by altering the reward-aversion balance. The aim of this chapter is not to question the importance of rewarding effects in self-administration but rather to provide evidence that aversive effects are an important factor that needs to be considered in discussions of drug-taking behavior.

AB - Drugs of abuse are typically discussed in terms of their rewarding effects and how these effects mediate drug taking. However, these drugs produce aversive effects that could have an important role in the overall acceptability of a drug and its likelihood of being self-administered. Rewarding and aversive effects, then, could be interpreted as separate behavioral effects, with the balance of the two determining overall drug acceptability. Interestingly, the role of aversive effects on drug acceptability in the self-administration preparation has received limited attention in this context. This chapter examines the aversive effects of drugs and discusses their role in drug taking. If these aversive effects serve a protective function, manipulations that alter or decrease these effects could have implications for drug taking. Several factors have been reported to alter conditioned taste aversion (CTA) learning, a preparation used in the assessment of the aversive effects of drugs in general. Two of these factors, drug history and strain, are reviewed here. By reviewing these, we intend to demonstrate the protective nature of aversive effects in the initiation and escalation of drug taking and to provide evidence that reductions in aversive effects could produce changes in patterns of drug self-administration that could lead to an increased vulnerability to abuse drugs by altering the reward-aversion balance. The aim of this chapter is not to question the importance of rewarding effects in self-administration but rather to provide evidence that aversive effects are an important factor that needs to be considered in discussions of drug-taking behavior.

KW - Animal models

KW - Aversion

KW - Conditioned taste aversion

KW - Drug abuse

KW - Reward

UR - http://www.scopus.com/inward/record.url?scp=77949283892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949283892&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2009.05147.x

DO - 10.1111/j.1749-6632.2009.05147.x

M3 - Article

C2 - 20201857

AN - SCOPUS:77949283892

VL - 1187

SP - 247

EP - 275

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -