TY - JOUR
T1 - Conditioned gustatory avoidance induced by three cholinergic agents
AU - Preston, Kenzie L.
AU - Schuster, Charles R.
N1 - Funding Information:
Rats were randomly divided into 4 groups of 6 rats each. On the eighth and tenth days, all rats received bottles of sweetened condensed milk (Borden C. ; diluted 2 parts water to 1 part milk) at room temperature for 15 minutes in place of the water. Fifteen minutes after the milk was removed, each group of rats was given intraperitoneai injections of atropine SO~ (25 mg/kg), mecamylamine HCI (25 mg/kg), physostig- ~C. R. Schuster is a recipient of Career Scientist Award DA 00024 from the National Institute on Drug Abuse; K. L. Preston is supported by PHS5-T32 GM-07151 from the National Institute of General Medical Health. Address all correspondence to C. R. Schuster, Department of Psychiatry, The University of Chicago, 950 East 59th St., Chicago, IL 60637.
PY - 1981/11
Y1 - 1981/11
N2 - Conditioned gustatory avoidance of sweetened condensed milk was induced in rats by drugs which differentially affect the cholinergic nervous system. After baseline water intake during a 15 minute daily session was established, sweetened condensed milk was presented in place of water, followed 15 minutes later by an IP injection of saline, physostigmine (0.5 mg/kg), atropine (25 mg/kg) or mecamylamine (25 mg/kg). Three presentations of milk were given, alternating daily with a water presentation. Atropine, a muscarinic blocker, and mecamylamine, a nicotinic blocker, both produced a strong avoidance. Physostigmine, an indirect agonist, produced a less pronounced avoidance at the dose employed. This study indicates that cholinergic agonists and antagonists are capable of inducing conditioned gustatory avoidance.
AB - Conditioned gustatory avoidance of sweetened condensed milk was induced in rats by drugs which differentially affect the cholinergic nervous system. After baseline water intake during a 15 minute daily session was established, sweetened condensed milk was presented in place of water, followed 15 minutes later by an IP injection of saline, physostigmine (0.5 mg/kg), atropine (25 mg/kg) or mecamylamine (25 mg/kg). Three presentations of milk were given, alternating daily with a water presentation. Atropine, a muscarinic blocker, and mecamylamine, a nicotinic blocker, both produced a strong avoidance. Physostigmine, an indirect agonist, produced a less pronounced avoidance at the dose employed. This study indicates that cholinergic agonists and antagonists are capable of inducing conditioned gustatory avoidance.
KW - Atropine
KW - Conditioned gustatory avoidance
KW - Mecamylamine
KW - Physostigmine
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U2 - 10.1016/0091-3057(81)90030-7
DO - 10.1016/0091-3057(81)90030-7
M3 - Article
C2 - 7312919
AN - SCOPUS:0019791142
SN - 0091-3057
VL - 15
SP - 827
EP - 828
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 5
ER -