Les adénovirus réplicatifs conditionnels: Un second souffle pour la thérapie génique du cancer

Jacques Grill; Birgit Geoerger; Martine Lamfers; Clemens Dirven; Victor Van Beusechem; Winald Gerritsen; Gilles Vassal

Les adénovirus réplicatifs conditionnels: Un second souffle pour la thérapie génique du cancer

Translated title of the contribution: Conditionally replicative adenoviruses: A second wind for cancer gene therapy

Jacques Grill, Birgit Geoerger, Martine Lamfers, Clemens Dirven, Victor Van Beusechem, Winald Gerritsen, Gilles Vassal

Research output: Contribution to journal › Review article › peer-review

Abstract

Cancer gene therapy has offered many hopes but its first use in humans revealed some pitfalls and at least three main problems: lack of efficacy and specificity of current vectors to deliver therapeutic genes, poor diffusion of the therapeutic effects inside the tumor (absence of bystander effect), poor distribution of the vectors injected inside the tissue. To address some of these issues, several teams have developped tumor selective replicating adenoviruses, some of them being already in the clinic. First results are promissing but complementary studies are needed to define if these agents will take place in the therapeutic armentorium against cancer.

Translated title of the contribution	Conditionally replicative adenoviruses: A second wind for cancer gene therapy
Original language	French
Pages (from-to)	1039-1048
Number of pages	10
Journal	Bulletin du Cancer
Volume	90
Issue number	12
State	Published - Dec 2003
Externally published	Yes

Keywords

Oncolysis
Onyx 015
Replication
Virus

ASJC Scopus subject areas

Hematology
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

Cite this

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title = "Les ad{\'e}novirus r{\'e}plicatifs conditionnels: Un second souffle pour la th{\'e}rapie g{\'e}nique du cancer",

abstract = "Cancer gene therapy has offered many hopes but its first use in humans revealed some pitfalls and at least three main problems: lack of efficacy and specificity of current vectors to deliver therapeutic genes, poor diffusion of the therapeutic effects inside the tumor (absence of bystander effect), poor distribution of the vectors injected inside the tissue. To address some of these issues, several teams have developped tumor selective replicating adenoviruses, some of them being already in the clinic. First results are promissing but complementary studies are needed to define if these agents will take place in the therapeutic armentorium against cancer.",

keywords = "Oncolysis, Onyx 015, Replication, Virus",

author = "Jacques Grill and Birgit Geoerger and Martine Lamfers and Clemens Dirven and {Van Beusechem}, Victor and Winald Gerritsen and Gilles Vassal",

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T1 - Les adénovirus réplicatifs conditionnels

T2 - Un second souffle pour la thérapie génique du cancer

AU - Grill, Jacques

AU - Geoerger, Birgit

AU - Lamfers, Martine

AU - Dirven, Clemens

AU - Van Beusechem, Victor

AU - Gerritsen, Winald

AU - Vassal, Gilles

PY - 2003/12

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N2 - Cancer gene therapy has offered many hopes but its first use in humans revealed some pitfalls and at least three main problems: lack of efficacy and specificity of current vectors to deliver therapeutic genes, poor diffusion of the therapeutic effects inside the tumor (absence of bystander effect), poor distribution of the vectors injected inside the tissue. To address some of these issues, several teams have developped tumor selective replicating adenoviruses, some of them being already in the clinic. First results are promissing but complementary studies are needed to define if these agents will take place in the therapeutic armentorium against cancer.

AB - Cancer gene therapy has offered many hopes but its first use in humans revealed some pitfalls and at least three main problems: lack of efficacy and specificity of current vectors to deliver therapeutic genes, poor diffusion of the therapeutic effects inside the tumor (absence of bystander effect), poor distribution of the vectors injected inside the tissue. To address some of these issues, several teams have developped tumor selective replicating adenoviruses, some of them being already in the clinic. First results are promissing but complementary studies are needed to define if these agents will take place in the therapeutic armentorium against cancer.

KW - Oncolysis

KW - Onyx 015

KW - Replication

KW - Virus

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M3 - Review article

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AN - SCOPUS:0742322108

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Les adénovirus réplicatifs conditionnels: Un second souffle pour la thérapie génique du cancer

Abstract

Keywords

ASJC Scopus subject areas

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