Conditional Survival after Surgical Resection of Gastric Cancer

A Multi-Institutional Analysis of the US Gastric Cancer Collaborative

Yuhree Kim, Aslam Ejaz, Gaya Spolverato, Malcolm H. Squires, George Poultsides, Ryan C. Fields, Mark Bloomston, Sharon M. Weber, Konstantinos Votanopoulos, Alexandra W. Acher, Linda X. Jin, William G. Hawkins, Carl Schmidt, David Kooby, David Worhunsky, Neil Saunders, Clifford S. Cho, Edward A. Levine, Shishir K. Maithel, Timothy M. Pawlik

Research output: Contribution to journalArticle

Abstract

Background: Survival estimates following surgical resection of gastric adenocarcinoma are traditionally reported as survival from the date of surgery. Conditional survival (CS) estimates, however, may be more clinically relevant by accounting for time already survived. We assessed CS following surgical resection for gastric adenocarcinoma.

Conclusions: Survival estimates following surgical resection of gastric adenocarcinoma is dynamic; the probability of survival increases with time already survived. Patients with worse prognostic features at the time of surgery had the greatest increases in CS over time. Conditional survival estimates provide important information about the changing probability of survival over time and should be used among patients with resected gastric adenocarcinoma to guide subsequent follow-up strategies.

Methods: We analyzed 807 patients who underwent resection for gastric adenocarcinoma from 2000 to 2012 at seven participating institutions in the U.S. Gastric Cancer Collaborative. Cox proportional hazards models were used to evaluate factors associated with overall survival. Three-year CS estimates at “x” year after surgery were calculated as follows: CS3 = S(x+3)/S(x).

Results: Overall 1-, 3-, and 5-year overall survival rates after gastric resection were 42, 34, and 30 %, respectively. Using CS estimates, the probability of surviving an additional 3 years given that the patient had survived at 1, 3, and 5 years were 56, 71, and 82 %, respectively. Patients with higher risk at baseline (i.e., stage III or IV disease, lymphovascular invasion) demonstrated the greatest increase in CS over time.

Original languageEnglish (US)
Pages (from-to)557-564
Number of pages8
JournalAnnals of Surgical Oncology
Volume22
Issue number2
DOIs
StatePublished - 2014

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Stomach Neoplasms
Survival
Stomach
Adenocarcinoma
Proportional Hazards Models
Survival Rate

ASJC Scopus subject areas

  • Surgery
  • Oncology
  • Medicine(all)

Cite this

Conditional Survival after Surgical Resection of Gastric Cancer : A Multi-Institutional Analysis of the US Gastric Cancer Collaborative. / Kim, Yuhree; Ejaz, Aslam; Spolverato, Gaya; Squires, Malcolm H.; Poultsides, George; Fields, Ryan C.; Bloomston, Mark; Weber, Sharon M.; Votanopoulos, Konstantinos; Acher, Alexandra W.; Jin, Linda X.; Hawkins, William G.; Schmidt, Carl; Kooby, David; Worhunsky, David; Saunders, Neil; Cho, Clifford S.; Levine, Edward A.; Maithel, Shishir K.; Pawlik, Timothy M.

In: Annals of Surgical Oncology, Vol. 22, No. 2, 2014, p. 557-564.

Research output: Contribution to journalArticle

Kim, Y, Ejaz, A, Spolverato, G, Squires, MH, Poultsides, G, Fields, RC, Bloomston, M, Weber, SM, Votanopoulos, K, Acher, AW, Jin, LX, Hawkins, WG, Schmidt, C, Kooby, D, Worhunsky, D, Saunders, N, Cho, CS, Levine, EA, Maithel, SK & Pawlik, TM 2014, 'Conditional Survival after Surgical Resection of Gastric Cancer: A Multi-Institutional Analysis of the US Gastric Cancer Collaborative', Annals of Surgical Oncology, vol. 22, no. 2, pp. 557-564. https://doi.org/10.1245/s10434-014-4116-5
Kim, Yuhree ; Ejaz, Aslam ; Spolverato, Gaya ; Squires, Malcolm H. ; Poultsides, George ; Fields, Ryan C. ; Bloomston, Mark ; Weber, Sharon M. ; Votanopoulos, Konstantinos ; Acher, Alexandra W. ; Jin, Linda X. ; Hawkins, William G. ; Schmidt, Carl ; Kooby, David ; Worhunsky, David ; Saunders, Neil ; Cho, Clifford S. ; Levine, Edward A. ; Maithel, Shishir K. ; Pawlik, Timothy M. / Conditional Survival after Surgical Resection of Gastric Cancer : A Multi-Institutional Analysis of the US Gastric Cancer Collaborative. In: Annals of Surgical Oncology. 2014 ; Vol. 22, No. 2. pp. 557-564.
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abstract = "Background: Survival estimates following surgical resection of gastric adenocarcinoma are traditionally reported as survival from the date of surgery. Conditional survival (CS) estimates, however, may be more clinically relevant by accounting for time already survived. We assessed CS following surgical resection for gastric adenocarcinoma.Conclusions: Survival estimates following surgical resection of gastric adenocarcinoma is dynamic; the probability of survival increases with time already survived. Patients with worse prognostic features at the time of surgery had the greatest increases in CS over time. Conditional survival estimates provide important information about the changing probability of survival over time and should be used among patients with resected gastric adenocarcinoma to guide subsequent follow-up strategies.Methods: We analyzed 807 patients who underwent resection for gastric adenocarcinoma from 2000 to 2012 at seven participating institutions in the U.S. Gastric Cancer Collaborative. Cox proportional hazards models were used to evaluate factors associated with overall survival. Three-year CS estimates at “x” year after surgery were calculated as follows: CS3 = S(x+3)/S(x). Results: Overall 1-, 3-, and 5-year overall survival rates after gastric resection were 42, 34, and 30 {\%}, respectively. Using CS estimates, the probability of surviving an additional 3 years given that the patient had survived at 1, 3, and 5 years were 56, 71, and 82 {\%}, respectively. Patients with higher risk at baseline (i.e., stage III or IV disease, lymphovascular invasion) demonstrated the greatest increase in CS over time.",
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T1 - Conditional Survival after Surgical Resection of Gastric Cancer

T2 - A Multi-Institutional Analysis of the US Gastric Cancer Collaborative

AU - Kim, Yuhree

AU - Ejaz, Aslam

AU - Spolverato, Gaya

AU - Squires, Malcolm H.

AU - Poultsides, George

AU - Fields, Ryan C.

AU - Bloomston, Mark

AU - Weber, Sharon M.

AU - Votanopoulos, Konstantinos

AU - Acher, Alexandra W.

AU - Jin, Linda X.

AU - Hawkins, William G.

AU - Schmidt, Carl

AU - Kooby, David

AU - Worhunsky, David

AU - Saunders, Neil

AU - Cho, Clifford S.

AU - Levine, Edward A.

AU - Maithel, Shishir K.

AU - Pawlik, Timothy M.

PY - 2014

Y1 - 2014

N2 - Background: Survival estimates following surgical resection of gastric adenocarcinoma are traditionally reported as survival from the date of surgery. Conditional survival (CS) estimates, however, may be more clinically relevant by accounting for time already survived. We assessed CS following surgical resection for gastric adenocarcinoma.Conclusions: Survival estimates following surgical resection of gastric adenocarcinoma is dynamic; the probability of survival increases with time already survived. Patients with worse prognostic features at the time of surgery had the greatest increases in CS over time. Conditional survival estimates provide important information about the changing probability of survival over time and should be used among patients with resected gastric adenocarcinoma to guide subsequent follow-up strategies.Methods: We analyzed 807 patients who underwent resection for gastric adenocarcinoma from 2000 to 2012 at seven participating institutions in the U.S. Gastric Cancer Collaborative. Cox proportional hazards models were used to evaluate factors associated with overall survival. Three-year CS estimates at “x” year after surgery were calculated as follows: CS3 = S(x+3)/S(x). Results: Overall 1-, 3-, and 5-year overall survival rates after gastric resection were 42, 34, and 30 %, respectively. Using CS estimates, the probability of surviving an additional 3 years given that the patient had survived at 1, 3, and 5 years were 56, 71, and 82 %, respectively. Patients with higher risk at baseline (i.e., stage III or IV disease, lymphovascular invasion) demonstrated the greatest increase in CS over time.

AB - Background: Survival estimates following surgical resection of gastric adenocarcinoma are traditionally reported as survival from the date of surgery. Conditional survival (CS) estimates, however, may be more clinically relevant by accounting for time already survived. We assessed CS following surgical resection for gastric adenocarcinoma.Conclusions: Survival estimates following surgical resection of gastric adenocarcinoma is dynamic; the probability of survival increases with time already survived. Patients with worse prognostic features at the time of surgery had the greatest increases in CS over time. Conditional survival estimates provide important information about the changing probability of survival over time and should be used among patients with resected gastric adenocarcinoma to guide subsequent follow-up strategies.Methods: We analyzed 807 patients who underwent resection for gastric adenocarcinoma from 2000 to 2012 at seven participating institutions in the U.S. Gastric Cancer Collaborative. Cox proportional hazards models were used to evaluate factors associated with overall survival. Three-year CS estimates at “x” year after surgery were calculated as follows: CS3 = S(x+3)/S(x). Results: Overall 1-, 3-, and 5-year overall survival rates after gastric resection were 42, 34, and 30 %, respectively. Using CS estimates, the probability of surviving an additional 3 years given that the patient had survived at 1, 3, and 5 years were 56, 71, and 82 %, respectively. Patients with higher risk at baseline (i.e., stage III or IV disease, lymphovascular invasion) demonstrated the greatest increase in CS over time.

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